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益母草对大鼠在体子宫肌电活动的影响
引用本文:马永明,杨东焱,田治峰,瞿颂义,丁永辉,卫玉玲. 益母草对大鼠在体子宫肌电活动的影响[J]. 中国中药杂志, 2000, 25(6): 364-366
作者姓名:马永明  杨东焱  田治峰  瞿颂义  丁永辉  卫玉玲
作者单位:兰州医学院!甘肃兰州730000(马永明,杨东焱,田治峰,瞿颂义),甘肃省药品检验所!甘肃兰州730000(丁永辉,卫玉玲)
基金项目:甘肃省自然科学基金!资助项目 (ZR 97 0 71 )
摘    要:目的 :观察益母草水煎液对大鼠子宫肌电活动的影响并探讨其机理。方法 :在大鼠一侧子宫浆膜表面埋埴一对Ag AgCl双极电极并联机记录。分别给其腹腔内注射益母草水煎液 0.1ml,0.2ml及0.4ml,对大鼠子宫肌电活动的变化进行慢性实验观察。结果 :在注药后 ,大鼠子宫肌电的慢波频率加快、平均振幅增大 ;单波频率加快、最大振幅增大 ;爆发波时程延长、串间隔缩小、最大振幅增大 ,并与剂量有关。结论 :益母草对子宫的兴奋作用可能是通过改变了与电活动有关的一些离子浓度 ,使起步细胞电活动加强及动作电位去极化速度加快所致。

关 键 词:子宫肌电  益母草  大鼠  兴奋
收稿时间:1999-09-09

Effect of Motherwort Herb on The Myoelectric Activity of Uterus in Rats
MA Yong ming ;YANG Dong yan ;TIAN Zhi feng ;QU Song yi ;DING Yong hui ;WEI Yu ling. Effect of Motherwort Herb on The Myoelectric Activity of Uterus in Rats[J]. China Journal of Chinese Materia Medica, 2000, 25(6): 364-366
Authors:MA Yong ming   YANG Dong yan   TIAN Zhi feng   QU Song yi   DING Yong hui   WEI Yu ling
Affiliation:Lanzhou Medical College, Lanzhou 730000, Gansu, China.
Abstract:Objective:To investigate the effect of motherwort herb on the myoelectric activity of uterus in rats.Method:A pair of bipolar Ag AgCl electrode was implanted on the serosal surface of the uterus in rats,motherwort herb was injected intra abdominal cavity in rats in dose of 0.1 ml, 0.2 ml and 0.4 ml respectively, and the changes of uterine myoelectric activity were observed.Result:Motherwort herb significantly increased the frequency and average amplitude of uterus slow waves of in rats.The frequency and maximum amplitude of single waves also obviously increased.The time course of outbreak waves was prolonged,the series intervals were reduced and the maximum amplitude in each outbreak was increased.Conclusion:The exciting effect of motherwort herb on the uterine smooth muscle may have something to do with the alteration of the ion concentration in relation to myoelectric activity, resulting in the increase of myoelectric activity of pacesetter cells as well as in the acceleration of depolarization of spike activity.
Keywords:uterine myoelectricity  motherwort herb  rat  excitation.
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