| 芍药苷作用于神经系统的研究进展 |
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| 引用本文： | 胡增峣,徐岚,闫蓉,黄晏,刘港,周文霞,张永祥.芍药苷作用于神经系统的研究进展[J].中国中药杂志,2013,38(3):297-301. |
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| 作者姓名： | 胡增峣 徐岚 闫蓉 黄晏 刘港 周文霞 张永祥 |
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| 作者单位： | 军事医学科学院毒物药物研究所,北京,100850 |
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| 基金项目： | 国家"重大新药创制"科技重大专项(2012ZX09301003-002,2012ZX09J12201-002,2011ZXJ09201-011);国家自然科学基金青年基金项目(81100239) |
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| 摘 要： | 芍药苷是芍药的主要活性成分,药理作用多样,应用广泛.近来,芍药苷对神经系统的作用研究受到越来越多的关注.目前的研究结果认为,芍药苷对多种痴呆模型动物的学习记忆功能衰退有改善作用,对脑缺血损伤有明显的保护作用,对帕金森病有一定的治疗作用,还具有镇痛、改善神经突触可塑性损伤等作用.其作用机制尚未完全阐明,现有结果显示腺苷Al受体在其中发挥了较为重要的作用,M胆碱受体、阿片受体、Ca2+通道、NF-κB等也都可能参与了芍药苷对神经系统的作用.
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| 关 键 词： | 芍药苷 神经退行性疾病 脑缺血 腺苷A1受体 芍药内酯苷 |
| 收稿时间： | 2012/6/29 0:00:00 |
Advance in studies on effect of paeoniflorin on nervous system |
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| HU Zeng-yao,XU Lan,YAN Rong,HUANG Yan,LIU Gang,ZHOU Wen-xia and ZHANG Yong-xiang.Advance in studies on effect of paeoniflorin on nervous system[J].China Journal of Chinese Materia Medica,2013,38(3):297-301. |
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| Authors: | HU Zeng-yao XU Lan YAN Rong HUANG Yan LIU Gang ZHOU Wen-xia and ZHANG Yong-xiang |
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| Institution: | Research Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China;Research Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China;Research Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China;Research Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China;Research Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China;Research Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China;Research Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China |
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| Abstract: | |
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| Keywords: | paeoniflorin neurodegenerative disorders cerebral ischemia adenosine A1 receptor albiflorin |
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