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三棱、莪术抗大鼠免疫性肝纤维化研究
引用本文:袭柱婷,单长民,姜学连,栾希英,李珂珂.三棱、莪术抗大鼠免疫性肝纤维化研究[J].中国中药杂志,2002,27(12):929-932.
作者姓名:袭柱婷  单长民  姜学连  栾希英  李珂珂
作者单位:滨州医学院,山东,滨州,256603
基金项目:山东省教委科研发展计划项目资助(j97k58)
摘    要:目的:研究三棱、莪术抗肝纤维化的作用。方法:以腹腔注射猪血清制备大鼠肝纤维化模型,以ALT,GGT,TP,Alb,A/G比值,ⅣC,LN,HA及肝脏组织病理变化为指标,观察三棱、莪术对大鼠免疫性肝纤维化的影响。结果:三棱、莪术能提高肝纤维化大鼠TP,Alb含量及A/G比值,降低ALT,GGT,ⅣC,LN,HA的作用,并能改善肝脏组织病理学变化。结论:三棱、莪术有保护肝细胞、减轻肝细胞变性坏死,恢复肝细胞结构和功能;减少纤维组织增生、阻止纤维化发展,促进纤维组织降解的作用。

关 键 词:三棱  莪术  肝纤维化
文章编号:1001-5302(2002)12-0929-04
收稿时间:2001/5/28 0:00:00
修稿时间:2001年5月28日

Experimental Study on Rhizoma Sparganii and Radices Zedoariae Treating Hepatic Fibrosis
XI Zhu-ting;SHAN Chang-min;JIANG Xue-lian;LUAN Xi-ying;LI Ke-ke.Experimental Study on Rhizoma Sparganii and Radices Zedoariae Treating Hepatic Fibrosis[J].China Journal of Chinese Materia Medica,2002,27(12):929-932.
Authors:XI Zhu-ting;SHAN Chang-min;JIANG Xue-lian;LUAN Xi-ying;LI Ke-ke
Institution:Binzhou Medical College, Binzhou 256603, Shandong, China. xizt5216@x263.net
Abstract:Objective: To study the effects of rhizoma sparganii and radices zedoariae on hepatic fibrosis. Method: The rat im-munohepatic fibrosis model was made by intraperitoneal injection of porcine serum and treated with rhizoma sparganii and radices zedoariae. The ALT,GGT,TP, ALb, A/G, IVC,LN,HA and the pathological change of the liver were observed. Result: Rhizoma sparganii and radices zedoariae could increase TP, ALb, A/G, decrease ALT, GGT, IVC, LN, HA and improve the pathological change. Conclusion: Rhizoma sparganii and radices zedoariae can protect hepatic cells, alleviate degeneration and necrosis, recover structure and function, and reduce the proliferation of fibrous tissue.
Keywords:Rhizoma Sparganii  Radices Zedoariae  hepatic fibrosis
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