| 参芎注射液对缺血再灌注损伤大鼠炎症损伤的影响 |
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| 引用本文： | 周惠芬,艾进超,万海同,何昱,张宇燕,赵涛,付巍,杨洁红.参芎注射液对缺血再灌注损伤大鼠炎症损伤的影响[J].中国中药杂志,2015,40(12):2408-2412. |
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| 作者姓名： | 周惠芬 艾进超 万海同 何昱 张宇燕 赵涛 付巍 杨洁红 |
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| 作者单位： | 1. 浙江中医药大学,浙江杭州,310053
2. 山东步长制药有限公司,山东菏泽,274000 |
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| 基金项目： | 国家自然科学基金项目(81274176,81202636);浙江省卫生高层次创新人才培养工程项目 |
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| 摘 要： | 为研究参芎注射液对脑缺血再灌注老龄大鼠炎症损伤的影响.将84只SD大鼠随机分为假手术组、模型组、尼莫通组、参芎注射液高、中、低剂量组.连续腹腔注射给药3d,采用线栓法建立大鼠脑缺血再灌注模型,再灌注24h,神经功能评分,取脑TTC染色,ELISA法检测血清中肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)的含量,荧光实时定量PCR(RT-PCR)对海马区IL-1β,TNF-α,ICAM-1和MMP-9 mRNA的表达量进行检测.结果,参芎注射液可使脑梗死体积减少,明显改善神经功能,参芎注射液能减少IL-1β,TNF-α,ICAM-1和MMP-9 mRNA的表达量,并减少IL-1β和TNF-α的含量.表明参芎注射液对大鼠缺血再灌注损伤具有明显的保护作用,其机制可能与抑制炎症因子表达有关.
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| 关 键 词： | 参芎注射液 脑缺血再灌注损伤 TNF-α IL-1β ICAM-1 MMP-9 |
| 收稿时间： | 2014/10/30 0:00:00 |
Effect of Shenxiong injection on inflammation injury of ischemia- reperfusion injury rats |
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| ZHOU Hui-fen,AI Jin-chao,WAN Hai-tong,HE Yu,ZHANG Yu-yan,ZHAO Tao,FU Wei and YANG Jie-hong.Effect of Shenxiong injection on inflammation injury of ischemia- reperfusion injury rats[J].China Journal of Chinese Materia Medica,2015,40(12):2408-2412. |
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| Authors: | ZHOU Hui-fen AI Jin-chao WAN Hai-tong HE Yu ZHANG Yu-yan ZHAO Tao FU Wei and YANG Jie-hong |
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| Institution: | Zhejiang Chinese Medicine University, Hangzhou 310053, China,Zhejiang Chinese Medicine University, Hangzhou 310053, China,Zhejiang Chinese Medicine University, Hangzhou 310053, China,Zhejiang Chinese Medicine University, Hangzhou 310053, China,Zhejiang Chinese Medicine University, Hangzhou 310053, China,Shandong Buchang Pharmaceutical Company Limited, Heze 274000, China,Shandong Buchang Pharmaceutical Company Limited, Heze 274000, China and Zhejiang Chinese Medicine University, Hangzhou 310053, China |
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| Abstract: | |
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| Keywords: | Shenxiong injection cerebral ischemia-reperfusion injury TNF-α IL-1β ICAM-1 MMP-9 |
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