首页 | 本学科首页   官方微博 | 高级检索  
检索        

一测多评法在冠脉康胶囊多种成分检测中的应用研究
引用本文:邹桂欣,尤献民,张颖,王光函,姜鸿.一测多评法在冠脉康胶囊多种成分检测中的应用研究[J].中国中药杂志,2008,33(15):1828-1831.
作者姓名:邹桂欣  尤献民  张颖  王光函  姜鸿
作者单位:辽宁省中医药研究院,辽宁,沈阳,110034
摘    要:目的:将适合于中药特点的的利用1个对照品同步测定多组分的分析方法首次应用于中药复方制剂的质量控制中。方法:以葛根素为指标,建立冠脉康胶囊中该成分与大豆苷元及丹酚酸B的相对校正因子,用校正因子计算大豆苷元及丹酚酸B的含量,同时对一测多评的计算与外标法实测值进行比较,并对不同品牌填料及不同长度的色谱柱进行考查,评价一测多评法在复方制剂中应用的准确性和科学性。结果:建立了冠脉康胶囊的含量控制方法,方法准确性评价结果表明,利用一测多评法在不同色谱柱的计算值与外标实测值之间没有显著性差异。结论:用本法可不提供大豆苷元及丹酚酸B的对照品,只采用葛根素对照品即可同时控制三者的含量,适合中药的多指标质量评价模式的要求。

关 键 词:一测多评  中药复方制剂  HPLC  冠脉康胶囊  校正因子
收稿时间:2008/1/14 0:00:00

New method of multi-components quantitation by one marker new method for quality evaluation of Guanmaikang capsula
ZOU Gui-xin; YOU Xian-min; ZHANG Ying; WANG Guang-han; JIANG Hong.New method of multi-components quantitation by one marker new method for quality evaluation of Guanmaikang capsula[J].China Journal of Chinese Materia Medica,2008,33(15):1828-1831.
Authors:ZOU Gui-xin; YOU Xian-min; ZHANG Ying; WANG Guang-han; JIANG Hong
Abstract:Obiective: To establish a new quality evaluation method for traditional Chinese medicine preparations, using one chemical reference substance to calcutate multi-components simultaneously. Method: Employed puerarin as the maker component, puerarin relative correction factors (RCF) of salvianolic acid B to puerarin and paidzein to puerarin were calcatated in the chromatographic conditions for determination of the three components in Guanmaikang capsules. The contents of Puerarin were determined by external standard method, and those of salvianolic acid B and paidzein were calculated by puerarin and their RCF . The accuracy of the new method was evaluated by comparing the calculated contents with the determined. Result: The analysis methods were established, and it has been no significant difference between the calculated contents and determined contents. Conculsions: The method can control the components without providing salvianolic acid B and paidzein reference. It is to be a suitable quality evaluation pattern for TCM Preparation.
Keywords:multi-components quantitive by one maker  Guanmaikang capsula  HPLC  relative correction factor
本文献已被 维普 万方数据 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号