香港市售天雄补肾助阳药效学研究

目的 :探讨天雄补肾助阳药效机理 ,为进一步研究开发炮天雄治肾阳虚证新药提供实验依据。方法 :采用常规阳虚证和肾虚证动物模型 ,观察低温游泳存活时间、脏器系数、阴茎勃起潜伏期等指标。结果 :炮天雄煎剂能提高阳虚证小鼠耐疲劳能力 ,延长其低温存活时间 ,促进肾虚证大鼠免疫作用。结论 :炮天雄具有一定的补肾助阳功效 ,与其历代文献记载“补命门、强肾气”和现在港澳中医临床治疗肾亏阳虚证相吻合。

Pharmacological Study on Tianxiong(Tuber of Aconitum carmichaeli Debx.), A Chinese Drug for Reinforcing the Kidney Yang Retail in Hong Kong Market

OBJECTIVE: To explore the pharmacodynamic mechanism of Tianxiong (Aconitum carmichaeli) in tonifying the kidney and supporting Yang, so as to provide evidences for further development of new drugs treating Yang-eficiency of the kidney. METHOD: Observing parameters such as visceral index, survival time of low-temperature swimming for hydrocortisone-induced Yang-deficiency model mouse and testis-removed kidney-deficiency model rat. RESULT: The decoction of processed Tianxiong could strengthen the antifatigual ability and prolong the survival time of low-temperature swimming for mice, and promote immunization in rats. CONCLUSION: Tianxiong is able to reinforce the kidney Yang, which reconforms the conclusion of "replenishing the fire of vital gate and the Qi of kidney" recorded in Chinese historical literature and proved by overseas clinical practice.