药性热力学观及实践

中药药性理论一直是中医药基础研究的难点和热点,但至今尚未取得重要突破。寒热辨证为中医首要辨证,寒热药性是中药的首要药性,"寒者热之、热者寒之"是中医首要治则,但是究竟寒热药性是否客观存在?能否/如何建立一套客观可行的寒热药性评价方法体系?如何以寒热药性理论及其研究成果指导中医药实践?近年来课题组独辟蹊径,主要从热力学角度对中药寒热药性进行了一系列探索和研究,首次提出了"中医药(药性)热力学观"(thermodynam ic outlook of Ch inesem ed ic ine),建立了"源于临床,证于实验,回归临床"的中药药性研究模式,研制开发一套可用于中药寒热药性差异表征与评价的方法体系(包括冷热板差示法,微量量热法,药性循证医学分析),从体外到体内、从实验到临床,较系统地考察了机体新陈代谢过程中的能量转移和热变化及其不同寒热药性中药的干预效果,揭示中药寒热药性差异的客观性以及"寒者热之、热者寒之"的科学性,为审视和研究中药药性理论提供了新的视角和方法,为中医药现代化发展提供了新的科技支持。

Thermodynamic outlook and practice of Chinese medicinal nature

Medicinal nature theory of Chinese medicine is the difficult and hot issue in the basic research of Chinese medicine (CM), but has not yet obtained some important breakthrough until now. The Cold and Heat syndromes is considered as the capital differentiation of CM in clinic; Cold and Hot is the primary medicinal nature of CM.'Treating the Cold with Heat, the Heat with Cold' is the main therapeutic principle of CM. But, whether the Cold and Hot of medicinal nature objectively exists? Whether/how to establish a set of objectives and feasible appraisal methodologies? How to apply the theoratical and research findings of Medicinal nature in clinical practice? In recent years, a new road for ourselves to carry out a series of explorations and researches on the Cold and Hot nature of CM from the thermodynamic view has been opened, and the doctrine of "Thermodynamic outlook of Chinese medicinal nature" has been proposed firstly by our research group. Consequently, we have established the research model, "coming from clinic, verifying in experiment and returning to the clinic", on the medicinal nature of CM, and developed a set of appraisal methodologies of the Cold and Hot nature of Chinese medicine based on biothermokinetics, such as the Cold/Hot plate differentiating system, microcalorimetry, evidence-based medical analysis for medicinal nature of CM. Based on these methods, a systematical investigation has been done focusing the energy transfer and thermal change in the metabolism progress of organism and the intervention effects of different Chinese medicines on this progress from the experiment to the clinic, in vitro and in vivo. Our studies have essentially elucidated the objectivity of the differences between the Cold and Hot nature of Chinese medicine as well as the scientific connotation of "treating the Cold with Heat, the Heat with Cold", provided a novel and perspective approach for investigating the medicinal nature theory of Chinese medicine, further supplied some new technological supports for the modernization of CM.