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| 黄蜀葵花制剂治疗慢性肾脏病的机制和疗效 | |
| 引用本文： | 陈萍,万毅刚,王朝俊,赵青,魏晴雪,涂玥,尹雪皎.黄蜀葵花制剂治疗慢性肾脏病的机制和疗效[J].中国中药杂志,2012,37(15):2252-2256. |
| 作者姓名： | 陈萍 万毅刚 王朝俊 赵青 魏晴雪 涂玥 尹雪皎 |
| 作者单位： | 1. 南京大学医学院附属鼓楼医院中医科,江苏南京,210008 2. 昆山市中医医院,江苏昆山,215300 3. 南京中医药大学中西医结合鼓楼临床医学院,江苏南京,210008 4. 南京中医药大学研究生院,江苏南京,210046 |
| 基金项目： | 南京市卫生青年人才培训工程项目;江苏高校优势学科建设工程项目 |
| 摘 要： | 黄蜀葵花Abelmoschus manihot(AM)中分离出20余种生物活性成分,包括黄酮类、多糖类、鞣酸类以及长链烃类等化合物。其中,主要化学成分是AM总黄酮(total flavones of A.manihot,TFA)。AM制剂——"黄葵胶囊"治疗慢性肾脏病(chronic kidney disease,CKD)的机制主要包括抑制免疫反应、减轻炎症反应、改善肾纤维化、保护肾小管上皮细胞等。在临床上,黄葵胶囊可以治疗肾病综合征、糖尿病肾病、紫癜性肾炎、IgA肾病、膜性肾病等常见CKD。其临床疗效主要表现在改善CKD患者临床症状,减少蛋白尿和血尿,提高肾功能等方面。 |
| 关 键 词： | 慢性肾脏病 黄蜀葵花 药理机制 临床疗效 |
| 收稿时间： | 2011/9/20 0:00:00 |
Mechanisms and effects of Abelmoschus manihot preparations in treating chronic kidney disease |
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| CHEN Ping,WAN Yigang,WANG Chaojun,ZHAO Qing,WEI Qingxue,TU Yue and YIN Xuejiao.Mechanisms and effects of Abelmoschus manihot preparations in treating chronic kidney disease[J].China Journal of Chinese Materia Medica,2012,37(15):2252-2256. | |
| Authors: | CHEN Ping WAN Yigang WANG Chaojun ZHAO Qing WEI Qingxue TU Yue and YIN Xuejiao |
| Institution: | Department of Traditional Chinese Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China;Department of Traditional Chinese Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China;Kunshan Hospital of Traditional Chinese Medicine, Kunshan 215300, China;Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjng 210008, China;Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjng 210008, China;Department of Graduate School, Nanjing University of Chinese Medicine, Nanjng 210046, China;Department of Graduate School, Nanjing University of Chinese Medicine, Nanjng 210046, China |
| Abstract: | Abelmoschus manihot(AM) is a medicinal plant rich in twenty kinds of separated active bio-components including flavones,polysaccharides,trannic acid,and long chain hydrocarbons.Among these,total flavones of A.manihot(TFA) are the major active component.In this review,the mechanisms of Huangkui capsule will be discussed as a preparation of AM to treat chronic kidney disease(CKD) by improving immunological reaction,inflammation,renal fibrosis,and renal tubular epithelial injury.Additionally,it has been reported that Huangkui capsule can ameliorate some clinical symptoms,proteinuria,hematuria,and renal function in patients with common CKD,such as nephrotic syndrome,diabetic nephropathy,Henoch-Schnlein purpura nephritis,IgA nephropathy,and membranous nephropathy. |
| Keywords: | chronic kidney disease Abelmoschus manihot mechanism clinical effect |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |