| 板蓝根的化学成分研究 |
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| 引用本文： | 左丽,李建北,徐景,杨敬芝,张东明,佟永领.板蓝根的化学成分研究[J].中国中药杂志,2007,32(8):688-691. |
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| 作者姓名： | 左丽 李建北 徐景 杨敬芝 张东明 佟永领 |
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| 作者单位： | 1. 中国医学科学院,中国协和医科大学,药物研究所,中草药物质基础与资源利用教育部重点实验室,北京,100050
2. 天津中新药业集团股份有限公司,第六中药厂,天津,300401 |
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| 摘 要： | 目的：对板蓝根的化学成分进行分离和鉴定。方法：采用正相、反相、凝胶柱色谱和高效液相制备方法进行分离纯化,利用波谱数据和理化常数鉴定化合物的结构。结果：从乙醇提取物中分离鉴定了11个化合物,分别为：(+)-异落叶松树脂醇(1),(+)-落叶松树脂醇(2),落叶松树脂醇-9-O-β-D-吡喃型葡萄糖苷(3),落叶松树脂醇-4′-O-β-D-吡喃型葡萄糖苷(4),落叶松树脂醇-4,4′-二-O-β-D-吡喃型葡萄糖苷(5),3-甲酰吲哚(6),1-methoxy-3-indolecarbaldehyde(7),1-methoxy-3-indoleacetonitrile(8),deoxyvasicinone(9),表告依春(10),腺苷(11)。结论：化合物4～8均为首次从该植物中分离得到。
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| 关 键 词： | 板蓝根 化学成分 |
| 文章编号： | 1001-5302（2007）08-0688-04 |
| 收稿时间： | 2006-09-22 |
| 修稿时间： | 2006-09-22 |
Studies on chemical constituents in root of Isatis indigotica |
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| ZUO Li; LI Jian-bei; XU Jing; YANG Jing-zhi; ZHANG Dong-ming; TONG Yong-ling.Studies on chemical constituents in root of Isatis indigotica[J].China Journal of Chinese Materia Medica,2007,32(8):688-691. |
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| Authors: | ZUO Li; LI Jian-bei; XU Jing; YANG Jing-zhi; ZHANG Dong-ming; TONG Yong-ling |
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| Institution: | Institute of Materia Medica, CAMS & PUMC, Beijing 100050, China. |
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| Abstract: | OBJECTIVE: To study the chemical constituents in the root of Isatis indigotica. METHOD: The constituents root were separated through various chromatographic techniques and their structures were elucidated by means of physicochemical properties and the analysis of their spectral data. RESULT: Eleven compounds were isolated and identified as (+) -isolariciresinol (1), lariciresinol (2), lariciresinol-9-O-beta-D-glucopyranoside (3), lariciresinol-4'-O-beta-D-glucopyranoside (4), lariciresinol-4,4'-bis-O-beta-D-glucopyranoside (5), 3-formylindole (6), 1-methoxy-3-indolecarbaldehyde (7), 1-methoxy-3-indoleacetonitrile (8), deoxyvasicinone (9), epigoitrin (10), adenosine (11). CONCLUSION: Compounds 4-8 were isolated from I. indigotica for the first time. |
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| Keywords: | Isatis indigotica chemical constituents |
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