| 菊叶千里光乙酸乙酯部位化学成分研究 |
| |
| 引用本文： | 林生,张中晓,沈云亨,李慧梁,单磊,柳润辉,徐希科,张卫东.菊叶千里光乙酸乙酯部位化学成分研究[J].中国中药杂志,2010,35(9):1137-1141. |
| |
| 作者姓名： | 林生 张中晓 沈云亨 李慧梁 单磊 柳润辉 徐希科 张卫东 |
| |
| 作者单位： | 1. 第二军医大学药学院,上海,200433
2. 第二军医大学药学院,上海,200433;上海交通大学药学院,上海,200240 |
| |
| 基金项目： | 上海市科技基金 (07DZ19728, 06DZ19717, 06DZ19005) |
| |
| 摘 要： | 目的:对菊科千里光属植物菊叶千里光Senecio chrysanthemoides全草乙醇提取物的乙酸乙酯部位的化学成分进行系统的研究.方法:采用硅胶、Sephadex LH-20柱色谱、薄层制备和制备型高效液相色谱方法进行分离;应用NMR和MS等波谱方法鉴定化合物的结构.结果:从菊叶千里光的乙酸乙酯部位分离得到25个化合物,分别鉴定为千里光菲林碱(1),千里光碱(2),1,2-dihydrocacalohastine(3),桉叶醇-4(15)-烯-1β,6α-二醇(4),7,11,15-三甲基-3-亚甲基十六烷-1,2-二醇(5),款冬二醇3-O-棕榈酸酯(6),马尼拉二醇3-O-棕榈酸酯(7),款冬二醇(8),马尼拉二醇(9),β-香树脂醇(10),α-香树脂醇(11),自桦脂醇(12),loranthol(13),(+)-丁香树脂酚(14),1-羟基-4-酮-环己烯-1-乙酸酯(15),2,6-二甲氧基对苯醌(16),豆甾-5,22-二烯-3β-羟基-7-酮(17),豆甾-5,22-二烯-7-酮(18),豆甾4-烯-3-酮(19),豆甾-4,22-二烯-3-酮(20),β-谷甾醇(21),豆甾醇(22),胡萝卜苷(23),十一烷酸甘油酯(24)和十一烷酸甲酯(25).讨论:化合物5～9,13,17～20和24均为首次从该属植物中分离得到.
|
| 关 键 词： | 菊科 千里光属 菊叶千里光 化学成分 |
| 收稿时间： | 2009/12/24 0:00:00 |
Ethyl acetate-soluble chemical constituents from whole plantsof Senecio chrysanthemoides |
| |
| LIN Sheng,ZHANF Zhongxiao,SHEN Yunheng,LI Huiliang,SHAN Lei,LIU Runhui,XU Xike and ZHANF Weidong.Ethyl acetate-soluble chemical constituents from whole plantsof Senecio chrysanthemoides[J].China Journal of Chinese Materia Medica,2010,35(9):1137-1141. |
| |
| Authors: | LIN Sheng ZHANF Zhongxiao SHEN Yunheng LI Huiliang SHAN Lei LIU Runhui XU Xike and ZHANF Weidong |
| |
| Institution: | College of Pharmacy, Second Military Medical University, Shanghai 200433, China;College of Pharmacy, Second Military Medical University, Shanghai 200433, China;College of Pharmacy, Second Military Medical University, Shanghai 200433, China;College of Pharmacy, Second Military Medical University, Shanghai 200433, China;College of Pharmacy, Second Military Medical University, Shanghai 200433, China;College of Pharmacy, Second Military Medical University, Shanghai 200433, China;College of Pharmacy, Second Military Medical University, Shanghai 200433, China;College of Pharmacy, Second Military Medical University, Shanghai 200433, China;College of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China |
| |
| Abstract: | Objective:To investigate the chemical constituents from the whole plants of Senecio chrysanthemoides. Method: The chemical constituents were isolated and purified by chromatographic techniques over silica gel, Sephadex LH-20, preparative TLC and preparative HPLC. Structures of the compounds were identified by NMR and MS spectroscopic methods. Result: Twenty five compounds were obtained and their structures were elucidated as seneciphyline (1), senecionine (2), 1,2-dihydrocacalohastine (3), eudesm-4(15)-ene-... |
| |
| Keywords: | Compositae Senecio L Senecio chrysanthemoides chemical constituents |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
