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| 三棱丸抑制大鼠子宫内膜异位症血管生成及VEGF,TNF-α表达的研究 | |
| 引用本文： | 陈怡,徐晓玉,叶兰,祝慧凤,陈红,陈刚.三棱丸抑制大鼠子宫内膜异位症血管生成及VEGF,TNF-α表达的研究[J].中国中药杂志,2008,33(3):303-307. |
| 作者姓名： | 陈怡 徐晓玉 叶兰 祝慧凤 陈红 陈刚 |
| 作者单位： | 1. 西南大学,药学院,中医药学院,重庆,400716 2. 贵阳医学院,药理教研室,贵州,贵阳,55004 3. 第三军医大学西南医院药剂科,重庆,400038 4. 重庆工商大学药物中心,重庆,400067 |
| 摘 要： | 目的:考察三棱丸(SLW)抑制子宫内膜异位症(EMS)血管生成作用及机制。方法:以SLW作用于子宫内膜异位症大鼠模型,免疫组化方法检测异位内膜组织中微血管密度(MVD)、血管生成因子VEGF及TNF-α蛋白的表达,RT-PCR方法检测异位组织中VEGF mRNA和TNF-α mRNA的表达。结果:SLW能有效降低MVD,抑制异位内膜组织中VEGF,TNF-α蛋白和mRNA的水平。结论:SLW具有良好的抗EMS血管生成作用,其作用机制与抑制血管生成因子VEGF,TNF-α的水平有关。 |
| 关 键 词： | 三棱丸 子宫内膜异位症 血管生成 VEGF TNF-α |
| 文章编号： | 1001-5302（2008）03-0303-05 |
| 收稿时间： | 8/2/2007 12:00:00 AM |
| 修稿时间： | 2007年8月2日 |
Inhibitory effects of Sanleng pellet on angiogenesis of endometriosis in rats |
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| CHEN Yi ;XU Xiao-yu ;YE Lan ;ZHU Hui-feng ;CHEN Hong ;CHEN Gong.Inhibitory effects of Sanleng pellet on angiogenesis of endometriosis in rats[J].China Journal of Chinese Materia Medica,2008,33(3):303-307. | |
| Authors: | CHEN Yi ;XU Xiao-yu ;YE Lan ;ZHU Hui-feng ;CHEN Hong ;CHEN Gong |
| Institution: | School of Pharmaceutical and Chinese Traditional Pharmaceutical Sciences, Southwest University, Chongqing 400716, China. |
| Abstract: | OBJECTIVE: To investigate the effect of Sanleng pellet on angiogenesis of endometriosis in SD rats. METHOD: The rat model of endometriosis were treated with Sanleng pellet. Observe microvessels density by immunohistochemical test as well as the expression of vascular endothelial growth factor and tumor necrosis factor-alpha in ectopic endometriotic tissue by immunohistochemical test and RT-PCR. RESULT: Sanleng pellet can reduce MVD, and inhibit the level of protein and mRNA of vascular endothelial growth factor and TNF-alpha in ectopic endometriotic tissue. CONCLUSION: Sanleng pellet can reduce the degree of angiogenesis in the endometriosis rats, and its mechanism might be associated with inhibiting the expression of vascular endothelial growth factor and TNF-alpha in the heterotopic tissue. |
| Keywords: | Sanleng pellet endometriosis angiogenesis vascular endothelial growth factor tumor necrosis factor-alpha |
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