生化汤提取物对正常未孕、雌激素预处理及产后小鼠离体子宫平滑肌收缩功能的影响

目的:研究生化汤不同含量水提取物对正常未孕小鼠、雌激素预处理小鼠及产后小鼠子宫平滑肌收缩功能的影响。方法:采用正常未孕小鼠、雌激素预处理小鼠及产后小鼠离体子宫标本,以Medlab生物信号采集处理系统记录生化汤水提取物(3～12 mg.mL^-1)对子宫的收缩幅度及频率的影响。结果:生化汤水提取物对正常未孕小鼠及产后小鼠子宫的影响主要表现为活动力减弱;对雌激素预处理小鼠子宫收缩频率及子宫活动力均表现为明显增强,且未见明显量效关系。结论:雌激素预处理小鼠子宫对生化汤的反应不能代表正常未孕及产后小鼠子宫的药理作用。

Effects of different concentration extract from Shenghua decoction on contractile activity of the uterine smooth muscle isolated from normal,estrogen-treated and postpartum mice

Objective: To investigate the effects of different concentration extract from Shenghua decoction on contractile activity of the uterine smooth muscle isolated from normal, estrogen-treated and postpartum mice.Method: Medlab/4 s vital signal recorder was used to measure the effects of extract from Shenghua decoction(3-12 mg·mL^-1) on contractile amplitude and frequency of the isolated uterus from normal,estrogen-treated and postpartum mice.Result: Shenghua decoction extract(3-12 mg·mL^-1) significantly decreased the contractile activity of the mouse isolated uterus in normal non-pregnancy and postpartum,but significantly increased that of the mouse isolated uterus treated with estrogen,and didn't show significant concentration-response relationship.Conclusion: The effects of Shenghua decoction extract on contractile activity of mouse-isolated uterus treated with estrogen cannot represent the pharmacological effects on that of in normal non-pregnancy and postpartum uterus.