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叶下珠抗肝细胞损伤作用机制
引用本文:周世文,徐传福,周宁,黄永平,黄林清,陈晓红,胡友梅,廖雅琴.叶下珠抗肝细胞损伤作用机制[J].中国中药杂志,1997,22(2):109-111.
作者姓名:周世文  徐传福  周宁  黄永平  黄林清  陈晓红  胡友梅  廖雅琴
作者单位:第三军医大学第二附属医院临床药理基地 重庆 630037;第三军医大学药理学教研室 重庆 630038
基金项目:中国人民解放军青年基金
摘    要:叶下珠能明显降低CCl4引起的小鼠血清ALT的升高,抑制肝脏MDA的生成。叶下珠体外与大鼠肝细胞共同孵育,能抑制CCl4所致肝细胞膜流动性降低,降低〔Ca2+〕i浓度。结果提示,叶下珠保护肝脏损伤作用可能与其抗指质过氧化和膜保护作用有关。

关 键 词:叶下珠  ALT  MDA  细胞膜流动性  〔Ca2+〕i
收稿时间:1995/11/22 0:00:00

Mechanism of Protective Action of Phyllanthus urinaria L. Against Injuries of Liver Cells
Zhou Shiwen;Xu Chuanfu;Zhou Ning;Huang Yongping; Huang Linqing;Chen Xiaohong;Hu Youmei; Liao Yaqin.Mechanism of Protective Action of Phyllanthus urinaria L. Against Injuries of Liver Cells[J].China Journal of Chinese Materia Medica,1997,22(2):109-111.
Authors:Zhou Shiwen;Xu Chuanfu;Zhou Ning;Huang Yongping; Huang Linqing;Chen Xiaohong;Hu Youmei; Liao Yaqin
Abstract:It has been found out that the carbon tetrachloride (CCl4)-induced increase of serum glutamic-pyruvic transaminase (ALT) and elevation of MDA in liver of mice are significantly lowered by Phyllanthus urinaria in vivo, and the coincubation of isolated rat hepatocytes with Phyllanthus urinaria in vitro significantly inhibits CCl4 induced decrease of mobility of membrane of liver cells and increase of intracellular free Ca2+(Ca2+]i) concentrations of liver cells. These results suggest that the anti lipid peroxidation effect and protective action of membrane of Phyllanthus urinaria may be related to its protective action against CCl4induced liver injuries.
Keywords:Phyllanthus urinaria  ALT  MDA  mobility of membrane  [Ca2+]I
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