| 大豆苷元抗心律失常作用的研究 |
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| 引用本文： | 叶和杨,邱峰,曾靖,姚新生,赖飞.大豆苷元抗心律失常作用的研究[J].中国中药杂志,2003,28(9):853-856. |
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| 作者姓名： | 叶和杨 邱峰 曾靖 姚新生 赖飞 |
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| 作者单位： | 1. 赣南医学院,药理教研室,江西,赣州,341000
2. 沈阳药科大学,植化教研室,辽宁,沈阳,110016 |
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| 摘 要： | 目的 :研究大豆苷元抗心律失常作用。方法 :常规抗心律失常方法。结果 :大豆苷元 (3.0,5.0mg·kg-1)对氯仿诱发的小鼠室颤有明显的预防作用 ,大豆苷元 (0.8,1.0mg·kg-1)对乌头碱诱发的大鼠心律失常有明显的治疗效果。大豆苷元 (0.2,0.3mg·kg-1)还能对抗肾上腺素诱发的家兔心律失常 ,大豆苷元 (0.03% ,0.05%)能明显降低蟾蜍离体坐骨神经动作电位振幅。大豆苷元 (0.8,1.0mg·kg-1)对氯化钙诱发的大鼠室颤具有预防作用 ,且能明显的降低大鼠的死亡率。以上作用具有明显的剂量依赖性。结论 :大豆苷元有明显的抗心律失常作用。其抗心律失常作用可能与其抑制Na+内流或Ca2+ 内流及与阻断-β 肾上腺素受体有关。
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| 关 键 词： | 大豆苷元 心律失常 动作电位 |
| 文章编号： | 1001-5302(2003)09-0853-03 |
| 收稿时间： | 2002/4/16 0:00:00 |
| 修稿时间： | 2002年4月16日 |
Effect of Daidzein on Antiarrhythmia |
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| YE He-Yang ;QIU Feng ;ZENG Jing ;YIAO Xing-sen ;LAI Fei.Effect of Daidzein on Antiarrhythmia[J].China Journal of Chinese Materia Medica,2003,28(9):853-856. |
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| Authors: | YE He-Yang ;QIU Feng ;ZENG Jing ;YIAO Xing-sen ;LAI Fei |
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| Institution: | Department of Pharmacology, Gan Nan Medical College, Ganzhou 341000, Jiangxi, China. heyangye@sohu.com |
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| Abstract: | OBJECTIVE: To study the effect of Daidzein on Antiarrhythmia. METHOD: The conventional antiarrhythmia methods were used. RESULT: Daidzein was remarkedly effective in preventing ventricular fibrillation induced by chloroform in mice and arrhythmia induced by aconitine in rats. The arrhythmia induced by adrenalin in rabbits was antagonized by Daidzein and it could obviously inhibit the action potential amplitude of isolated sciatic nerves in toads. And it could also prevent ventricular fibrillation induced by calcium chloride in rats, and obviously reduce the death rate of rats. Its anti-arrhythmic effect was dose-dependent. CONCLUSION: Daidzein has obvious protective effect on drug-induced arrhythmia, which may be related to its inhibition of Na+ or Ca2+ influx and its blocking beta-adrenergic receptor. |
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| Keywords: | Daidzein arrhythmia action potential |
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