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| 中药延缓糖尿病肾病肾小球硬化的作用机制 | |
| 引用本文： | 陈婧,万毅刚,卞茸文,顾刘宝,王朝俊,张慧兰,姚建.中药延缓糖尿病肾病肾小球硬化的作用机制[J].中国中药杂志,2010,35(4):525-530. |
| 作者姓名： | 陈婧 万毅刚 卞茸文 顾刘宝 王朝俊 张慧兰 姚建 |
| 作者单位： | 1. 南京中医药大学,中西医结合鼓楼临床学院,江苏,南京,210008 2. 南京大学医学院,附属鼓楼医院,中医科,江苏,南京,210008 3. 江苏省老年医学研究所,江苏,南京,210029 4. Department of Molecular Signaling Interdisciplinary Graduate School of Medicine and Engineering,University of Yamanashi,Yamanashi,409-3898,Japan |
| 基金项目： | 南京市科技发展计划项目(200905006) |
| 摘 要： | 糖尿病肾病(diabetic nephropathy,DN)发病过程中所出现的肾小球硬化性损伤与糖代谢、足细胞、肾脏血流动力学、致纤维化细胞因子、氧化应激、炎症反应等因素有关.中药可以调节糖代谢异常,保护足细胞损伤,改善肾脏血流动力学障碍,下调致纤维化细胞因子表达,缓解氧化应激,抑制炎症反应等,从而延缓DN向终末期肾病发展的进程. |
| 关 键 词： | 糖尿病肾病 中药 药理机制 |
| 收稿时间： | 2009/10/15 0:00:00 |
Mechanism of Chinese herbal medicine delaying glomerulosclerosisin diabetic nephropathy |
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| CHEN Jing,WAN Yigang,BIAN Rongwen,GU Liubao,WANG Chaojun,ZHANG Huilan and YAO Jian.Mechanism of Chinese herbal medicine delaying glomerulosclerosisin diabetic nephropathy[J].China Journal of Chinese Materia Medica,2010,35(4):525-530. | |
| Authors: | CHEN Jing WAN Yigang BIAN Rongwen GU Liubao WANG Chaojun ZHANG Huilan and YAO Jian |
| Institution: | Drum Tower Clinical Institute of Combination of Traditional Chinese Medicine and Western Medicine, NanjingUniversity of Traditional Chinese Medicine, Nanjing 210008, China;Department of Traditional Chinese Medicine,The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China;Jiangsu Institutes of Geriatrics,Nanjing 210000, China;Jiangsu Institutes of Geriatrics,Nanjing 210000, China;Drum Tower Clinical Institute of Combination of Traditional Chinese Medicine and Western Medicine, NanjingUniversity of Traditional Chinese Medicine, Nanjing 210008, China;Drum Tower Clinical Institute of Combination of Traditional Chinese Medicine and Western Medicine, NanjingUniversity of Traditional Chinese Medicine, Nanjing 210008, China;Department of Molecular Signaling Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, 409-3898, Japan |
| Abstract: | The pathomechanisms of glomerulosclerosis in diabetic nephropathy (DN) are considered to be related with glycometabolism disorder, podocyte injury, intra-renal hemodynamics abnormality, fibrogenic cytokines over-expression, oxidative stress and inflammatory reaction. Chinese herbal medicine could delay the progression of glomerulosclerosis in DN by ameliorating the harmful factors of these pathological changes. Therefore, it is possible to postpone the progress of DN to end-stage renal disease through the treatment with Chinese herbal medicine. |
| Keywords: | diabetic nephropathy Chinese herbal medicine pharmacological mechanism |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |