| 炮制对大黄、虎杖抗氧化作用的影响 |
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| 引用本文： | 孔令东,杨澄,仇熙.炮制对大黄、虎杖抗氧化作用的影响[J].中国中药杂志,2001,26(6):388-391. |
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| 作者姓名： | 孔令东 杨澄 仇熙 |
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| 作者单位： | 南京大学生命科学学院 |
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| 摘 要： | 目的 :研究炮制对大黄、虎杖抗氧化作用的影响。方法 :采用体外氧自由基生成系统和羟自由基诱导的小鼠肝匀浆脂质过氧化反应 ,评价炮制对大黄、虎杖抗氧化作用的影响。结果 :大黄、虎杖炮制品均可清除次黄嘌呤 黄嘌呤氧化酶系统所产生超氧阴离子 (O2·)以及Fenton反应生成的羟自由基 (·OH) ,并能抑制羟自由基诱导的小鼠肝脏匀浆脂质过氧化 ,各炮制品EC50之间有一定显著性差异。结论 :炮制降低大黄、虎杖抗氧化能力。
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| 关 键 词： | 大黄和虎杖炮制品 超氧阴离子 羟自由基 脂质过氧化 |
| 文章编号： | 1001-5302(2001)06-0388-04 |
| 收稿时间： | 2000/9/21 0:00:00 |
| 修稿时间： | 2000年9月21日 |
Effects of Processing on Antioxidation of Radix et Rhizoma Rhei and Rhizoma Polygoni Cuspidati |
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| KONG Ling dong;YANG Cheng;QIU Xi.Effects of Processing on Antioxidation of Radix et Rhizoma Rhei and Rhizoma Polygoni Cuspidati[J].China Journal of Chinese Materia Medica,2001,26(6):388-391. |
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| Authors: | KONG Ling dong;YANG Cheng;QIU Xi |
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| Institution: | Nanjing University, School of Life Sciences, State Key Laboratory of Pharmaceutial Biotechnology, Nanjing 210093, Jiangsu, China. |
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| Abstract: | Objective:To investigate the effects of Processing on antioxidation of Radix et Rhizoma Rhei and Rhizoma Polygoni Cuspidati. Method: The oxygen free radicals generation system and mouse liver homogenate lipid peroxidation in vitro were used. Result:The processed products of Radix et Rhizoma Rhei and Rhizoma Polygoni Cuspidati could scavenge superoxide radical (O2·)generated through hypoxanthine oxidase system and (·OH) generated through Fenton action, and inhibit lipid peroxidation induced by hydroxyl radical generation system, respectively. There existed significant differences among the different processed products. Conclusion:After Radix et Rhizoma Rhei and Rhizoma Polygoni Cuspidati were processed, their effects became weaker. |
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| Keywords: | processing products Radix et Rhizoma Rhei Rhizoma Polygoni Cuspidati superoxide radical hydroxyl radical lipid peroxidation |
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