基于医院信息系统的参麦注射液不同使用剂量对肾功能作用分析

目的: 了解参麦注射液不同使用剂量对肾功能是否有影响。 方法: 以全国18家三级甲等医院的医院信息系统(HIS)为数据来源,从中选择使用参麦注射液、年龄在18~80岁、使用参麦注射液前后7 d有2次血肌酐与尿素氮检测者作为研究对象,将患者2次理化指标测定期间内的最大单次给药剂量大于100 mL的纳入超说明书推荐剂量组,其余纳入未超说明书推荐剂量组。采用倾向性评分法,比较2组间肾功能发生异常的差异。 结果: 超说明书推荐剂量组与未超说明书推荐剂量组比较,导致血肌酐、尿素氮发生异常变化的可能性相同,统计学差异不显著。 结论: 基于现有数据,未发现"超说明书推荐剂量使用参麦注射液对肾功能有损害"的情况,但临床中用药仍需谨慎。

Based on hospital information system data, analysis of effects of different doses of Shenmai injection on renal function

Objective: To assess whether the dosage of Shenmai injection influences renal function. Method: Analysis of hospital information system(HIS) data from 18 national hospitals using Shenmai injections. Patients were aged between 18 to 80 years old. Blood analysis of creatinine and serum urea nitrogen was undertaken 7 days before and after exceeding the maximum recommended dose of 100 mL of Shenmai injection. Propensity score method was used to compare the differences between the two groups of renal function scores. Result: The differences in abnormal changes in creatinine and serum urea nitrogen levels between the groups before and after exceeding the recommended dose was not statistically significant, but abnormal changes were detected. Conclusion: Based on the available data we did not find that exceeding the recommended dose of Shenmai injection had a significantly deleterious effect on renal function. However, caution should be applied in its clinical use.