| 水杉总黄酮对压力超负荷大鼠左室肥厚的作用 |
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| 引用本文： | 曾加雄,刘惟莞,石明健,杨晓茹,糜留西,卢云英,郑庆安,王红英.水杉总黄酮对压力超负荷大鼠左室肥厚的作用[J].中国中药杂志,2000,25(10):622-624. |
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| 作者姓名： | 曾加雄 刘惟莞 石明健 杨晓茹 糜留西 卢云英 郑庆安 王红英 |
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| 作者单位： | 1. 湖北医科大学,药理教研室,湖北,武汉,430071
2. 中国科学院,武汉植物研究所,湖北,武汉,430074 |
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| 基金项目： | 国家自然科学基金资助项目!( 3 9770 0 88) |
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| 摘 要： | 目的：研究水杉总黄酮对压力超负荷大鼠左室肥厚的预防和逆转作用。方法：缩窄腹主动脉建立压力超负荷大鼠心肌肥厚模型，分别于术后1周和6周给予水杉总黄酮ig，持续6周。结果：预防和逆转部分，水杉总黄酮均能显著降低大鼠HW/BW、LVW/BW、心肌纤维直径和左心室肌Ca2＋含量，而使收缩压(SBP)仅轻微下降，结论：水杉总黄酮对压力超负荷大鼠左室肥厚有预防和逆转作用，其机制可能与钙拮抗作用有关。
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| 关 键 词： | 压力超负荷 左室肥厚 钙 |
| 收稿时间： | 1999/12/7 0:00:00 |
Effects of Total Flavones of Metasequosia on left Ventricular Hypertrophy Due to Pressure Overload in Rats |
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| ZENG Jia-Xing;LIU Wei-wan;SHI Ming-jian;Yang Xiao-ru;LU Yun-ying;WANG Hong-ying;Mi Liu-Xi;Zheng Qing-an.Effects of Total Flavones of Metasequosia on left Ventricular Hypertrophy Due to Pressure Overload in Rats[J].China Journal of Chinese Materia Medica,2000,25(10):622-624. |
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| Authors: | ZENG Jia-Xing;LIU Wei-wan;SHI Ming-jian;Yang Xiao-ru;LU Yun-ying;WANG Hong-ying;Mi Liu-Xi;Zheng Qing-an |
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| Institution: | Dept of Pharmacology, Hubei Medical University, Wuhan 430071, Hubei, China. |
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| Abstract: | OBJECTIVE: To determine the preventive and regressive effects of total flavones of metasequosia (TFM) on left ventricular hypertrophy in rats. METHOD: Left ventricular hypertrophy was inducedin by partial ligation of abdominal aorta. The rats were given ig TFM(4, 40, 400 mg.kg-1.d-1) for six weeks. RESULT: TFM markedly reduced the HW/BW, LVW/BW, myofibril diameter and Ca2+ content in left ventricles but the systolic blood pressure (SBP) in rats wasn't obviously influenced. CONCLUSION: TFM can prevent and reverse the left ventricular hypertrophy due to pressure overload in rats. The mechanism may be related to its calcium antagonistic properties. |
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| Keywords: | pressure overload left ventricular hypertrophy calcium |
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