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| 络石藤中微量化学成分的分离及结构鉴定 | |
| 引用本文： | 景玲,于能江,赵毅民,李玉山.络石藤中微量化学成分的分离及结构鉴定[J].中国中药杂志,2012,37(11):1581-1585. |
| 作者姓名： | 景玲 于能江 赵毅民 李玉山 |
| 作者单位： | 1. 军事医学科学院毒物药物研究所,北京100850;沈阳药科大学中药学院,辽宁沈阳110016 2. 军事医学科学院毒物药物研究所,北京,100850 3. 沈阳药科大学中药学院,辽宁沈阳,110016 |
| 基金项目： | 国家 "重大新药创制"科技重大专项(2009ZX09301-002) |
| 摘 要： | 目的:研究中药络石藤的微量化学成分。方法:采用聚酰胺,硅胶,Sephadex LH-20,ODS等柱色谱方法进行分离纯化,并通过分析波谱数据确定化学结构。结果:从络石藤中分离得到11个化合物,分别鉴定为岩白菜素(1),柯伊利素-7-O-β-D-葡萄糖苷(2),牛蒡子苷元-4’-O-β-龙胆二糖苷(3),罗汉松树脂酚-4’-O-β-龙胆二糖苷(4),紫花络石苷元(5),紫花络石苷(6),4-去甲基紫花络石苷元(7),木樨草素-7-O-β-龙胆二糖苷(8),牛蒡子苷(9),络石苷元-4’-O-β-龙胆二糖苷(10),木樨草素-7-O-β-D-葡萄糖苷(11)。结论:化合物1,2为首次从该属植物中分离得到,化合物3～7为首次从该植物中分离得到。 |
| 关 键 词： | 络石藤 微量化学成分 结构鉴定 |
| 收稿时间： | 2011/9/14 0:00:00 |
Trace chemical constituents contained in Trachelospermum jasminoides and structure identification |
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| JING Ling,YU Nengjiang,ZHAO Yimin and LI Yushan.Trace chemical constituents contained in Trachelospermum jasminoides and structure identification[J].China Journal of Chinese Materia Medica,2012,37(11):1581-1585. | |
| Authors: | JING Ling YU Nengjiang ZHAO Yimin and LI Yushan |
| Institution: | Institute of Pharmacology and Toxicology, Academy of Military Medical sciences, Beijing 100850, China;School of Traditional Chinese Medicines, Shenyang Pharmaceutical University, Shenyang 110016, China;Institute of Pharmacology and Toxicology, Academy of Military Medical sciences, Beijing 100850, China;Institute of Pharmacology and Toxicology, Academy of Military Medical sciences, Beijing 100850, China;School of Traditional Chinese Medicines, Shenyang Pharmaceutical University, Shenyang 110016, China |
| Abstract: | Objective: To study trace chemical constituents contained in traditional Chinese medicine Trachelospermum jasminoides.Method: The chemical constituents were separated and purified by using such column chromatographic methods as ployamide,silica gel,Sephadex LH-20 and ODS,and their structures were identified on the basis of spectral data analysis.Result: Eleven compounds were separated from T.jasminoides and identified as bergenin(1),chrysoeriol-7-O-β-D-glucoside(2),arctigenin-4′-O-β-gentiobioside(3),matairesinol-4′-O-β-gentiobioside(4),traxillagenin(5),traxillaside(6),4-demethyltraxillagenin(7),luteolin-7-O-β-gentiobioside(8),arctiin(9),trachelogenin-4′-O-β-gentiobioside(10) and luteolin-7-O-β-D-glucoside(11).Conclusion: Compounds 1 and 2 were separated from Trachelospermum genus for the first time,while compounds 3-7 were separated from this plant for the first time. |
| Keywords: | Trachelospermum jasminoides trace chemical constituent structure identification |
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