基于原位质谱技术的中药质量评价策略的构建

中药质量是保障中医药临床安全有效的基础,中药质量准确评价是中医药标准化、现代化发展的桥梁。伴随国家大力推动中药质量提升和加强中药质量安全监管,复杂中药样品质量的快速、精准评价依然是目前中药研究的瓶颈问题。笔者结合近年来在原位质谱技术开发及其在复杂中药体系质量评价应用中的体会,构建了系列基于原位质谱技术的多场景中药质量评价策略。在复杂中药煎煮体系质量实时监测、复方中成药快速毒性分级及中成药原料药追踪评价等具体领域形成了较为系统的方法体系,有效解决了传统分析技术难以实现的多场景复杂中药分析难题,以期为实现快速、精准的中药质量评价提供普适性的研究思路与技术方法,助力中药产业高质量发展。

Construction of quality evaluation strategy for Chinese medicine based on ambient mass spectrometry

Quality is the guarantee for the clinical safety and effectiveness of Chinese medicine.Accurate quality evaluation is the key to the standardization and modernization of Chinese medicine.Efforts have been made in improving Chinese medicine quality and strengthening the quality and safety supervision in China,but rapid and accurate quality evaluation of complex Chinese medicine samples is still a challenge.On the basis of the development of ambient mass spectrometry and the application in quality evaluation of complex Chinese medicine systems in recent years,the authors developed the multi-scenario Chinese medicine quality evaluation strategies.A systematic methodology was proposed in specific areas such as real-time monitoring of the quality of complex Chinese medicine decoction system,rapid toxicity grading of compound Chinese patent medicine,and evaluation of bulk medicinals of Chinese patent medicine.Allowing multi-scenario analysis of Chinese medicine,it is expected to provide universal research ideas and technical methods for rapid and accurate quality evaluation of Chinese medicine and boost the high-quality development of Chinese medicine industry.