| 加压溶剂法提取雷公藤多苷及其条件优化 |
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| 引用本文： | 杨磊,李彤,祖元刚.加压溶剂法提取雷公藤多苷及其条件优化[J].中国中药杂志,2010,35(1):44-48. |
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| 作者姓名： | 杨磊 李彤 祖元刚 |
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| 作者单位： | 东北林业大学,森林植物生态学教育部重点实验室,黑龙江,哈尔滨,150040 |
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| 基金项目： | 国家"十一五"科技支撑计划项目(2006BAD18B04) |
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| 摘 要： | 目的:对卫矛科药用植物雷公藤提取方法进行研究。方法:利用加压溶剂提取方法进行提取分离,根据理化性质用显色-比色法进行定量分析,并在单因素试验基础上,根据中心组合试验设计原理采用3因素3水平的响应面分析法进行工艺优化。结果:经过响应面分析法得出优化的工艺条件为料液比1∶9.5,提取温度115℃,提取时间80 m in,在此条件下雷公藤多苷的浸膏得率可达0.21%,纯度为0.52%。结论:加压溶剂提取方法与常规提取法相比优势明显,是一种有效的提取分离方法。
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| 关 键 词： | 雷公藤 雷公藤多苷 加压提取 响应面 |
| 收稿时间： | 2009/9/17 0:00:00 |
Pressurized liquid extraction of Tripterygiumw wilfordii polyglycosides andoptimization of extraction conditions |
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| YANG Lei,LI Tong and ZU Yuangang.Pressurized liquid extraction of Tripterygiumw wilfordii polyglycosides andoptimization of extraction conditions[J].China Journal of Chinese Materia Medica,2010,35(1):44-48. |
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| Authors: | YANG Lei LI Tong and ZU Yuangang |
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| Institution: | Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040,China;Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040,China;Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040,China |
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| Abstract: | Objective : To study the solubilization of O/W microemulsion system for volatile oil from Houttuynia Cordra and determine the formulation of its microemulsion. Method : The solubilization curve was drawn from pseudo-ternary phase diagram plotted by using the method of titration. The microemulsion's effect on solubilization for volatile oil from Houttuynia Cordra was systematically studied and the difference solubilization effects between colloid fluid and microemulsion were compared. Result : Excipient varieties and amount of microemulsion had effects on solubilization for volatile oil from Houttuynia Cordra. The formulation of its microemulsion was determined and we chose medium-chain triglycerides as oil phase, polyoxyethylene castor oil EL-35 as surfactant,propylene glycol as cosurfactant and the surfactant to cosurfactant ratio was 2. Conclusion : Suitable microemulsion formulation can solubilize volatile oil from Houttuynia Cordra and it can provide research foundation for further development of microemulsion preparation for volatile oil from Houttuynia Cordra. |
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| Keywords: | Tripterygium wilfordii polyglycosides pressurized liquid extraction response surface methodology |
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