猪殃殃酚性成分研究

目的:对猪殃殃Galium aparine var.tenerum全草中酚性成分进行研究.方法:采用各种色谱法分离,运用多种波谱技术鉴定化合物结构.结果:从猪殃殃乙醇提取物的醋酸乙酯萃取部位分离鉴定了6个化合物,分别鉴定为对羟基苯乙酮(1),香草酸(2),3,4-二羟基苯甲酸(3),对羟基桂皮酸(4),没食子酸(5),4-羟基古柯间二酸(6).结论:化合物6为首次从天然产物中得到,并运用二维核磁共振波谱技术(~1H-~1H COSY,HMQC和HMBC)首次对其碳谱和氢谱数据进行了全归属,化合物1-5均为首次从该属植物中得到.

Phenolic compounds from Galium aparine var.tenerum

Objective: To study the compounds from the whole plant of Galium aparine var.tenerum. Method: The various column chromatographic techniques were applied to isolate the chemical constituents.MS, NMR and 2D-NMR spectroscopic techniques were uesd to identify chemical structures. Result: Six compounds were isolated from the EtOAc-soluble part of the 95% ethanol extract of the plant, and their chemical structures were identified as 1-(4-hydroxypheny1)-ethanone (1), vanillic acid (2), 3,4-dihydroxybenzoic acid (3), P-hydroxycinnamic acid (4), gallic acid (5), 4-hydroxytruxillic acid (6). Conclusion: The NMR data of compound 6 were completely assigned by 2D-NMR techniques,including¹H-¹H COSY, HMQC and HMBC spectra.This was the first time to report isolation of the compound 6 from natural product.The compounds 1-5 was isolated from the genus Galium for the first time.