| 慢性肾脏病肠道菌群失调的病理机制、治疗策略及中药的干预作用 |
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| 引用本文： | 韩文贝,刘莹露,万毅刚,孙伟,涂玥,杨晶晶,吴薇,何伟明,姚建.慢性肾脏病肠道菌群失调的病理机制、治疗策略及中药的干预作用[J].中国中药杂志,2017,42(13):2425-2432. |
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| 作者姓名： | 韩文贝 刘莹露 万毅刚 孙伟 涂玥 杨晶晶 吴薇 何伟明 姚建 |
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| 作者单位： | 南京中医药大学 中西医结合鼓楼临床医学院 中医科, 江苏 南京 210008,南京中医药大学 中西医结合鼓楼临床医学院 中医科, 江苏 南京 210008,南京大学 医学院 附属鼓楼医院 中医科, 江苏 南京 210008,南京中医药大学 附属医院 肾内科, 江苏 南京 210029,南京中医药大学 第二临床医学院 中医养生学教研室, 江苏 南京 210023,南京中医药大学 中西医结合鼓楼临床医学院 中医科, 江苏 南京 210008,南京中医药大学 中西医结合鼓楼临床医学院 中医科, 江苏 南京 210008,南京中医药大学 附属医院 肾内科, 江苏 南京 210029,Division of Molecular Signaling, Department of Advanced Biomedical Research, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi 409-3898, Japan |
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| 基金项目： | 国家自然科学基金面上项目（81374030,81373604,81573903）;国家自然科学基金青年科学基金项目（81603675）;国家自然科学基金青年科学基金项目（021414380219）;江苏省自然科学基金青年科学基金项目（BK20161046）;江苏省高校自然科学研究面上项目（16KJB360004） |
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| 摘 要： | 肠道菌群失调是中、晚期慢性肾脏病(chronic kidney disease,CKD)进展至尿毒症的高危因素之一,其特征就是益生菌减少、能产生尿毒素的条件致病菌(产尿素酶菌群、产内毒素菌群以及产代谢毒素菌群)增多。"肠-肾轴(gut-kidney axis)"学说和"慢性肾脏病-结肠轴(chronic kidney disease-colonic axis)"概念的核心观点认为,失调的肠道菌群通过加剧尿毒素蓄积和诱导全身性微炎症反应等途径加重肾脏的损伤。初步的临床试验和动物实验的结果显示,以乳酸菌和双歧杆菌制剂为代表的益生菌和以菊粉、低聚半乳糖为代表的益生元,还有鲁比前列酮、活性炭吸附剂等都可以针对CKD患者体内失调的肠道菌群,通过减轻尿毒素蓄积和抑制全身性微炎症反应等途径而改善肾功能。不仅如此,一些经口服或肠道给药的单味中药、中药复方还有中药提取物(大黄素等)在一定程度上也能调节肠道细菌,保护肠道上皮屏障,减轻尿毒素蓄积,延缓CKD进展。其中,大黄类经方——大黄甘草汤(浓缩颗粒TJ-84)改善肾衰竭动物模型体内尿毒素蓄积的靶点不是肾脏,而可能是"肠道菌群所启动的肠-肾轴"。基于此,针对中、晚期CKD患者肠组织中肠道菌群相关的病理因素(紧密连接蛋白、辅助性和调节性T细胞等)的干预性研究可能是今后的重点发展方向之一。
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| 关 键 词： | 肠道菌群 中药 慢性肾脏病 肠-肾轴 病理机制 |
| 收稿时间： | 2017/5/2 0:00:00 |
Pathomechanism and treatment of gut microbiota dysbiosis in chronic kidney disease and interventional effects of Chinese herbal medicine |
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| HAN Wen-bei,LIU Ying-lu,WAN Yi-gang,SUN Wei,TU Yue,YANG Jing-jing,WU Wei,HE Wei-ming and YAO Jian.Pathomechanism and treatment of gut microbiota dysbiosis in chronic kidney disease and interventional effects of Chinese herbal medicine[J].China Journal of Chinese Materia Medica,2017,42(13):2425-2432. |
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| Authors: | HAN Wen-bei LIU Ying-lu WAN Yi-gang SUN Wei TU Yue YANG Jing-jing WU Wei HE Wei-ming and YAO Jian |
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| Institution: | Department of Traditional Chinese Medicine, Nanjing Drum Tower Hospital Clinical College of Chinese Medicine and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210008, China,Department of Traditional Chinese Medicine, Nanjing Drum Tower Hospital Clinical College of Chinese Medicine and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210008, China,Department of Traditional Chinese Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China,Department of Nephrology, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China,Department of Traditional Chinese Medicine Health Preservation, Second Clinic Medical School, Nanjing University of Chinese Medicine, Nanjing 210023, China,Department of Traditional Chinese Medicine, Nanjing Drum Tower Hospital Clinical College of Chinese Medicine and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210008, China,Department of Traditional Chinese Medicine, Nanjing Drum Tower Hospital Clinical College of Chinese Medicine and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210008, China,Department of Nephrology, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China and Division of Molecular Signaling, Department of Advanced Biomedical Research, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi 409-3898, Japan |
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| Abstract: | |
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| Keywords: | gut microbiota Chinese herbal medicine chronic kidney disease gut-kidney axis pathomechanism |
| 本文献已被 CNKI 等数据库收录！ |
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