| 黄花紫玉盘枝、叶中的生物碱和蒽醌类化合物 |
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| 引用本文： | 吕子明,张庆建,陈若芸,于德泉.黄花紫玉盘枝、叶中的生物碱和蒽醌类化合物[J].中国中药杂志,2011,36(9):1190-1192. |
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| 作者姓名： | 吕子明 张庆建 陈若芸 于德泉 |
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| 作者单位： | 中国医学科学院,北京协和医学院,药物研究所,中草药物质基础与资源利用教育部重点实验室,北京,100050 |
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| 摘 要： | 目的:对黄花紫玉盘Uvaria kurzii枝、叶的化学成分进行分离鉴定,并进行体外细胞毒活性筛选.方法:以硅胶和Sephadex LH-20色谱柱进行分离纯化,根据理化性质和波谱数据鉴定化合物结构.采用MTT法对所得化合物进行5种人肿瘤细胞系的生物活性检测.结果:分离鉴定了9个化合物,分别为bidebiline A(1),annobraine(2),oxoputerine(3),atherospermidine(4),鹅掌楸碱(5),大黄素甲醚(6),大黄素-8-甲醚(7),甲基异茜草素-1-甲醚(8),大黄素(9).结论:化合物1～4,6～9为本属中首次分到.体外活性筛选结果表明3～5对A549,Bel7402,BGC823,HCT-8,A2780等多种癌细胞有生长抑制作用.
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| 关 键 词： | 番荔枝科 黄花紫玉盘 化学成分 生物碱 蒽醌类 细胞毒活性 |
| 收稿时间： | 2010/9/26 0:00:00 |
Alkaloids and anthraquinones from branches and leaves of Uvaria kurzii |
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| LV Ziming,ZHANG Qingjian,CHEN Ruoyun and YU Dequan.Alkaloids and anthraquinones from branches and leaves of Uvaria kurzii[J].China Journal of Chinese Materia Medica,2011,36(9):1190-1192. |
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| Authors: | LV Ziming ZHANG Qingjian CHEN Ruoyun and YU Dequan |
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| Institution: | Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China |
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| Abstract: | Objective : To investigate the chemical constituents of the branches and leaves of Uvaria kurzii. Method : The compounds were isolated and purified by silica gel and Sephadex LH-20 column chromatographic methods. Their chemical structures were elucidated on the basis of physicochemical properties and spectral data. Result : Nine compounds were isolated and identified as: bidebiline A( 1 ), annobraine ( 2 ), oxoputerine ( 3 ), atherospermidine ( 4 ), liriodenine ( 5 ), physcion ( 6 ), questin ( 7 ), rubiadin 3-methyl ether ( 8 ), emodin ( 9 ). Conclusion : Compound 1-4, 6-9 were isolated from the genus Uvaria for the first time. Compound 3-5 showed inhabitation activities against tumor cell lines A549, Bel7402, BGC823, HCT-8, A2780, respectively. |
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| Keywords: | Annonaceae Uvaria kurzii chemical constitutents alkaloids anthraquinones cytotoxicity |
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