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芍药苷对沙土鼠不全性脑缺血后能量代谢、NO和NOS的影响
引用本文:孙蓉,吕丽莉,刘国卿.芍药苷对沙土鼠不全性脑缺血后能量代谢、NO和NOS的影响[J].中国中药杂志,2006,31(10):832-835.
作者姓名:孙蓉  吕丽莉  刘国卿
作者单位:1. 中国药科大学,江苏,南京,210009;山东省中医药研究院,山东,济南,250014
2. 山东省中医药研究院,山东,济南,250014
3. 中国药科大学,江苏,南京,210009
摘    要:目的:观察芍药苷抗不全性脑缺血后脑组织能量代谢、NO和NOS的关系。方法:采用沙土鼠双侧颈总动脉夹闭脑缺血再灌注模型,于再灌注后48 h取前脑皮质测定Na+-K+-ATP酶、Ca2+-ATP酶、Mg2+-ATP酶、乳酸、NO和NOS水平。结果:与假手术对照组比较,缺血再灌注后48 h脑组织Na+-K+-ATP酶、Ca2+-ATP酶及Mg2+-ATP酶活性均降低,NO含量和NOS活性降低,而乳酸含量无明显变化。与模型对照组比较,芍药苷高、中、低剂量均可不同程度地防止缺血再灌注48 h后Na+-K+-ATP酶活性的降低,增加Ca2+-ATP酶和Mg2+-ATP酶活性,增加NO含量,提高NOS活性。结论:芍药苷通过调节脑内能量代谢和NO的生成而发挥抗脑缺血作用。

关 键 词:芍药苷  不全性脑缺血再灌注损伤  ATP酶  一氧化氮  一氧化氮合酶
文章编号:1001-5302(2006)10-0832-04
收稿时间:2005-07-14
修稿时间:2005-07-14

Effects of paeoniflorin on cerebral energy metabolism,nitric oxide and nitric oxide synthase after cerebral ischemia in mongoliagerbils
SUN Rong,;LV Li-li,;LIU Guo-qing.Effects of paeoniflorin on cerebral energy metabolism,nitric oxide and nitric oxide synthase after cerebral ischemia in mongoliagerbils[J].China Journal of Chinese Materia Medica,2006,31(10):832-835.
Authors:SUN Rong  ;LV Li-li  ;LIU Guo-qing
Institution:1. Department of pharmacology , China Pharmaceutical University, Nanjing 210009, China; 2. Shandong Research Academy of Traditional Chinese Medicine, Jinan 250014, China
Abstract:Objective: To explore the effects of paeoniflorin on antagonising the delayed neuronal death(DND) induced by cerebral ischemia,and the relation between DND,cerebral tissue energy metabolism,nitric oxide(NO) and nitric oxide synthase(NOS).Method: Incomplete cerebral ischemia induced was induced by ligating bilateral arteries carotis communis for 20 min followed by reperfusion 48 h in rats.The indexes including Na+-K+-ATPase activity,lactic acid content,Ca2+-ATPase,Mg2+-ATPase activity,NO content and NOS activity were determined in fore brain cortex at 48 h after reperfusion.Result: Na+-K+-ATPase,Ca2+-ATPase and Mg2+-ATPase activity were lowered((P<0.01)),NO level was decreased(P<0.01),NOS activity dropped(P<0.01) in cerebral tissue at 48h after reperfusion,but lactic acid level had no change.Paeoniflorin could prevent reduction of Na+-K+-ATPase activity(P<0.05,P<0.01),increase NO level((P<0.01)),enhance NOS activity(P<0.01) at 48h after reperfusion.Conclusion: DND induced by ischemia may be concerned with energy metabolism disorder and decrease of NO formation.Paeoniflorin may play the role of antagonising cerebral ischemia by adjusting cerebral energy metabolism and nitric oxide formation.
Keywords:paeoniflorin  cerebral ischemia  reperfusion injury  ATPase  nitric oxide  nitric oxide sythase
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