Network Pharmacology Bridges Traditional Application and Modern Development of Traditional Chinese Medicine |
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Authors: | Chang-xiao Liu Rui Liu Hui-rong Fan Xue-feng Xiao Xiao-peng Chen Hai-yu Xu and Yan-ping Lin |
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Institution: | School of Chinese Materia Medica,Tianjin University of Traditional Chinese Medicine;Department of Molecular Biosciences,School of Veterinary Medicine,University of California;Tasly Academy,Tasly Holding Group;Institute of Chinese Materia Medica,Chinese Academy of Traditional Chinese Medicine; |
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Abstract: | Traditional Chinese medicine (TCM) has developed over thousands of years and has accumulated abundant clinical experience, forming a comprehensive and unique medical system. Emerging evidence has begun to illustrate TCM as an area of important medical rediscoveries. This review article briefly introduced the concept, significance, and technology of network pharmacology based on network biology and systems biology. It focused on the theoretical system and potential prospect of TCM network applied in TCM research and development including predicting new drug targets, action mechanism, new drug discovery; evaluating pharmacodynamics, pharmacokinetics, safety, toxicology, quality control, and bioinformatics of drugs. We also discussed the opportunities and challenges in the development and application of network pharmacology in the modernization of TCM research. |
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Keywords: | network biology network pharmacology systems biology traditional Chinese medicine |
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