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| 草血竭抗肿瘤作用的实验研究 | |
| 引用本文： | 李文广,张小郁,陈晓.草血竭抗肿瘤作用的实验研究[J].中药药理与临床,2001,17(6):31-32. |
| 作者姓名： | 李文广 张小郁 陈晓 |
| 作者单位： | 1. 兰州医学院药理学教研室,兰州,730000 2. 兰州医学院生理学教研室,兰州,730000 3. 兰州医学院第二附属医院普外科,兰州,730000 |
| 摘 要： | 目的：研究草血竭提取物的抗肿瘤作用。方法：体外实验采用台盼蓝拒染法和MTT法，体内实验采用小鼠移植性肿瘤S180和HepA模型。结果：草血竭体外抑制K562和HL60的IC50为26．2－36．7mg/L，1.6g/kg对S180和HepA抑制率分别为47．3％和52．9％。结论：草血竭在体内外均有抗肿瘤作用。 |
| 关 键 词： | 草血竭 抗肿瘤 移植性肿瘤S180 HepA |
Experament study on antitumor effects of Polygonum paleaceum |
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| Li Wenguang,Zhang Xiaoyu ,Chen Xiao.Experament study on antitumor effects of Polygonum paleaceum[J].Pharmacology and Clinics of Chinese Materia Medica,2001,17(6):31-32. | |
| Authors: | Li Wenguang Zhang Xiaoyu Chen Xiao |
| Institution: | Li Wenguang,Zhang Xiaoyu 1,Chen Xiao 2 |
| Abstract: | To study the antitumor effects of Polyg onum paleaceum alcohol extractive (PPE). Methods: Trypan blue dye exclusion and MTT metho ds were used in vitro, transplanted tumor of mice S180 and HepA were used in viv o. Results: IC 50 of PPE on K562 and HL60 at 24h were 26.2 and 36.7mg/L respectively in vitro, and in vivo the inhibition r ates of 1.6g/kg PPE on S180 and HepA were 47.3% and 52.9%, respectively. Conclusion: PPE exerts antitumor activity. |
| Keywords: | Polygonum paleaceum antitumor |
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