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槐定碱对自由活动大鼠海马脑电及组织形态学的影响
引用本文:李玉香,朱万平,陈晓霞,白洁.槐定碱对自由活动大鼠海马脑电及组织形态学的影响[J].中药药理与临床,2007,23(6):23-25.
作者姓名:李玉香  朱万平  陈晓霞  白洁
作者单位:1. 宁夏医学院生理教研室,银川,750004
2. 宁夏医学院组织学及胚胎学教研室,银川,750004
基金项目:宁夏医学院科研项目;宁夏自然科学基金
摘    要:目的:观察槐定碱对清醒自由活动大鼠海马脑电及组织形态学的影响。方法:利用立体定位仪将电极植入大鼠海马,一周后连接于BL-420生物机能实验系统,观察槐定碱腹腔注射大鼠的海马脑电波及组织学的改变。结果:腹腔注射槐定碱5~15分钟后大鼠海马出现痫样放电,海马神经元及胶质细胞发生损伤性改变。结论:槐定碱可诱发大鼠的海马痫样放电,并导致其组织形态学损伤性改变。

关 键 词:槐定碱  脑电图  海马

Effects of sophoridine on the morphological structure of hippocampus in rats
Li Yuxiang,Zhu Wanping,Chen Xiaoxia,Bai Jie.Effects of sophoridine on the morphological structure of hippocampus in rats[J].Pharmacology and Clinics of Chinese Materia Medica,2007,23(6):23-25.
Authors:Li Yuxiang  Zhu Wanping  Chen Xiaoxia  Bai Jie
Abstract:Objective:To observe the effects of sophoridine on the electroencephalograph and histomorphological structure of hippocampus in rats. Method: Stereotaxic frame was employed to imbed a tiny electrode which was connected to the BL-420 Biotech system to observe the EEG and HE staining was used to determine the histology and morphological structure of hippocampus induced by SR kindled epilepsy in rats. Result: 15min after sophridine was injected introperitoneally, EEG showed epileptiform discharges. Conclusion: Sophoridine can induce epileptiform discharge and cause neuron damages in hippocampus.
Keywords:sophoridine  electroencephalograph  hippocampus  morphological changes
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