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石榴皮对乙型肝炎病毒(HBV)的体外灭活作用及其临床意义
引用本文:张杰,詹炳炎,等.石榴皮对乙型肝炎病毒(HBV)的体外灭活作用及其临床意义[J].中药药理与临床,1997,13(4):29-31.
作者姓名:张杰  詹炳炎
作者单位:湖北医科大学附属第一医院泌尿外科,湖北医科大学病毒研究所
基金项目:国家计划生育委员会基金
摘    要:体外试验随石榴皮水提液浓度增高,HBV病毒形态出现成团聚集、外壳缺失、核壳破裂;并剂量依赖地抑制病毒DNA聚合酶活性;对病毒抗原抗体结合抑制的机理与特异性抗体免疫结合作用不同。提示可将石榴皮制备成阴道栓剂以预防乙肝病毒的性传播感染。

关 键 词:石榴皮  乙型肝炎病毒  体外灭活作用

Killing Effect of Punica granatum L. against HBV in vitro
Zhang Jie,Zhan Bingyan,Yao Xuejun,et al..Killing Effect of Punica granatum L. against HBV in vitro[J].Pharmacology and Clinics of Chinese Materia Medica,1997,13(4):29-31.
Authors:Zhang Jie  Zhan Bingyan  Yao Xuejun  
Abstract:Direct killing effect of acquous extract of the Punica granatum L.(PGL) against HBV were studied in vitro. By the PGL concentration increased,(1)the virus paticles were agglutinated, the shell were lacked and the capsid were broken;(2)HBV DNA polymease was inhibited with dose depentent ralation;(3)HBV immuno combination test of antigen antibody were partly inhibited, the mechanism was different from the specific immunoreaction of antigen antibody combination. The results suggested that PGL as a vaginal suppository should have an important significance in clinic to protect against HBV sexual transmitted infection.
Keywords:Punical granatum L    HBV  antivirus
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