芸苔生物碱对大鼠血液流变学、肠系膜微循环及家兔视网膜微循环的影响

酸式硫酸芸苔碱在大鼠实验性血淤模型上35mg/kg ip,可降低118S~(-1)切变率下的全血粘度,降低红细胞压积,提高血浆中纤维蛋白原含量,红细胞刚性指数无显著改变;可显著提高大鼠肠系膜微循环血流流速。以25mg/kg、35mg/kg ip,缩短微循环血流的停流时间,增加血流恢复比例;对正常家兔0.1mg/kg点眼可改善家兔眼底血管荧光造影下的微循环状态。

Effects of Brassica Alkaloid on Blood Rheology and Microcirculation of Mesentery of Rats,and on Microcirculation of Rabbit Retina

With the experimental model of rat blood stasis, bisulfated Brassica alkaloid, at the dosage of 35 mg/kg ip, decreased the blood viscosity at shearing of 118 s-1, decreased Hct, increased the content of fibrinogen in serum,and no obvious changes of erythrocyte fragility; significantly increased the blood flow rate of mesentery microcirculation. At the dosage of 25 mg/kg and 35 mg/kg ip, the time of microcirculation blood flow stopping shortened, the rate of blood flowing regained increased. Dropped eyes of rabbits, at the dosage of 0.1 mg/kg improved the microcirculation of eye fundus by FFA.