| 莪术油对小鼠肝癌细胞抑制作用的分子机理 |
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| 引用本文： | 石灵春,汪波,吴万垠,肖楚梅,何青莲.莪术油对小鼠肝癌细胞抑制作用的分子机理[J].中药药理与临床,2002,18(1):6-7. |
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| 作者姓名： | 石灵春 汪波 吴万垠 肖楚梅 何青莲 |
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| 作者单位： | 广州中医药大学第二临床学院病理科,广州,510120 |
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| 摘 要： | 目的 :研究莪术油抑制小鼠HepA肝癌细胞的分子机制。方法 :建立小鼠HepA肝癌模型 ,进行莪术油抑癌试验 ,并用免疫组化法检测细胞增殖核抗原 (PCNA)、细胞周期素D1(cyclinD1)的表达 ,探讨莪术油抑制小鼠肝癌的分子机理。结果 :莪术油治疗组的瘤重、PCNA标记指数、cyclinD1标记指数均低于生理盐水组 (P <0 .0 1)。结论 :莪术油可能是通过下调cyclinD1的表达 ,抑制PCNA的阳性表达率 ,进而抑制肿瘤的生长。
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| 关 键 词： | 肝癌 莪术油 cyclinD1 PCNA |
Study on molecule mechanism of inhibiting hepatoma of Curcuma aramatica oil in mice |
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| Shi Lianchun,Wang Bo,Wu Wanyin,Xiao Chumei,He Qinglian.Study on molecule mechanism of inhibiting hepatoma of Curcuma aramatica oil in mice[J].Pharmacology and Clinics of Chinese Materia Medica,2002,18(1):6-7. |
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| Authors: | Shi Lianchun Wang Bo Wu Wanyin Xiao Chumei He Qinglian |
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| Abstract: | Aim: To study the molecule mechanism of curcuma aramatica oil on inhibiting hepatoma in mice. Methods: The model of HepA liver carcinoma was istablished in mice. The expressions of PCNA and cyclin D 1 in the HepA liver carcinoma cells were detected by immunohistochemistry. Results: There were statistically significance differences between the CAO and saline treared groups in tumor weights, PCNA LI and cyclin D 1 LI (P<0.01). Conclusion: The Curcuma aramatica oil inhibited the expression of cyclin D 1 and PCNA, as a results it inhibited the growth of hepatic carcinoma. |
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| Keywords: | liver carcinoma Curcuma aramatica oil cyclin D 1 PCNA |
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