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芒果苷对脂多糖诱导慢性炎症的抗炎作用
引用本文:卫智权,邓家刚,阎莉,包传红.芒果苷对脂多糖诱导慢性炎症的抗炎作用[J].中药药理与临床,2011(2):43-45.
作者姓名:卫智权  邓家刚  阎莉  包传红
作者单位:广西医科大学;广西中医学院;
基金项目:国家自然科学基金资助项目(30973916); 广西科技厅自治区重点实验室培育项目(09320005)
摘    要:目的:探讨芒果苷对脂多糖(LPS)诱导慢性炎症的抗炎作用及其机制。方法:90只SD大鼠随机分为正常组、模型组、泼尼松5 mg/kg组与芒果苷200、100、50 mg/kg组。以LPS间断尾静脉注射建立慢性炎症模型,进行大鼠全血白细胞计数,ELISA测定血清超敏C反应蛋白(hs-CRP)、肿瘤坏死因子(TNF-α)、白细胞介素6(IL-6)、可溶性细胞间粘附分子1(sICAM-1),RT-PCR检测白细胞核转录因子κB(NF-κB)基因表达。结果:与模型组比较,芒果苷200 mg/kg组全血白细胞总数与血清hs-CRP、TNF-α、IL-6、sICAM-1水平明显降低(P<0.05),白细胞NF-κB基因表达下调(P<0.05)。结论:芒果苷可显著抑制LPS诱导的慢性炎症,其作用机制与其下调白细胞NF-κB基因表达而降低炎症因子水平有关。

关 键 词:芒果苷  慢性炎症  抗炎作用  核转录因子κB

The anti-inflammatory actions of mangiferin on the chronic inflammation induced by lipopolysaccharide
Wei Zhiquan,Deng Jiagang,Yan Li,Bao Chuanhong.The anti-inflammatory actions of mangiferin on the chronic inflammation induced by lipopolysaccharide[J].Pharmacology and Clinics of Chinese Materia Medica,2011(2):43-45.
Authors:Wei Zhiquan  Deng Jiagang  Yan Li  Bao Chuanhong
Institution:Wei Zhiquan1,Deng Jiagang2,Yan Li2,Bao Chuanhong2 (1 Guangxi Medical University,Nanning 530021,2 Guangxi Traditional Chinese Medicine University,Nanning 530001)
Abstract:Objective: To study the anti-inflammatory actions of mangiferin on the chronic inflammation induced by lipopolysaccharide and its mechanism.Methods: 90 SD rats were randomly divided into normal control,model control,positive drug prednisone control(5mg/kg) and mangiferin(200,100,50 mg/kg) group.The chronic inflammation models were established by intermittent lipopolysaccharide caudal vein injection.The leucocyte count was measured.The levels of serum high-sensitivity C-reactive protein(hs-CRP),tumor necrosi...
Keywords:mangiferin  chronic inflammation  anti-inflammation  nuclear factor kappa B  
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