| 葛根素对糖尿病大鼠胰岛素、血糖及血液流变学的影响 |
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| 引用本文： | 高天曙,梁瑞峰.葛根素对糖尿病大鼠胰岛素、血糖及血液流变学的影响[J].中药药理与临床,2011(6):31-33. |
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| 作者姓名： | 高天曙 梁瑞峰 |
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| 作者单位： | 河南省中医院;河南省中医药研究院; |
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| 摘 要： | 目的:观察葛根素对糖尿病性大鼠胰岛素、血糖及血液流变学的影响。方法:采用链脲佐菌素联合完全弗氏佐剂诱导糖尿病大鼠,将造模成功大鼠随机分为模型对照组,二甲双胍250mg/kg组,葛根素高剂量组(300mg/kg)、中剂量组(150mg/kg)和低剂量组(75mg/kg),各组连续灌胃给药60d,于给药后15 d、35 d、60 d,检测胰岛素和血糖,末次给药后检测糖化血红蛋白、超氧化物歧化酶(SOD)、丙二醛(MDA)及血液流变学指标。结果:与模型组相比,葛根素75、150及300mg/kg剂量组均能明显降低糖尿病大鼠的胰岛素、血糖和糖化血红蛋白的含量(P<0.01),显著升高糖尿病大鼠的SOD、降低MDA(P<0.05)。结论:葛根素能提高大鼠的抗氧化能力,改善大鼠的血液流变性。
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| 关 键 词： | 葛根素 糖尿病 糖化血红蛋白 血液流变学 |
Effects of puerarin on insulin,blood glucose and blood rheology of rats with diabetes |
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| Gao Tianshu,Liang Ruifeng.Effects of puerarin on insulin,blood glucose and blood rheology of rats with diabetes[J].Pharmacology and Clinics of Chinese Materia Medica,2011(6):31-33. |
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| Authors: | Gao Tianshu Liang Ruifeng |
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| Institution: | Gao Tianshu1,Liang Ruifeng2(1 Henan Province Hospital of Traditional Chinese Medicine,Zhengzhou 450002,2 Henan Province Chinese Medicine Research Institute,Zhengzhou 450004) |
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| Abstract: | Objective:To study the effects of puerarin on insulin,blood glucose and blood rheology of rats with diabetes.Methods:Diabetic rats were induced by associating streptozotocin(STZ) with freund's adjuvant complete,and then the diabetic rats were divided randomly into five groups:model control group,metformin group(250mg/kg),puerarin high-dose group(300 mg/kg),middle-dose group(150 mg/kg),low-dose group(75 mg/kg).Normal control group was established additionally.Puerarin was perfused into stomach in diabatic ra... |
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| Keywords: | puerarin diabetes glycated hemoglobin blood rheology |
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