| 茶多酚对大鼠脑缺血再灌注损伤的保护作用 |
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| 引用本文： | 李立中,吴基良,闵清,郑敏,刘忠民,何丽娅.茶多酚对大鼠脑缺血再灌注损伤的保护作用[J].中药药理与临床,1996,12(3):18-20. |
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| 作者姓名： | 李立中 吴基良 闵清 郑敏 刘忠民 何丽娅 |
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| 作者单位： | 咸宁医学院药理教研室(李立中，吴基良，闵清，郑敏)，咸宁医学院生化教研室(刘忠民，何丽娅) |
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| 摘 要： | 本文通过结扎大鼠双侧颈总动脉３０ｍｉｎ后再灌注６０ｍｉｎ造成脑缺血再灌注损伤模型，观察茶多酚（ＴＰ）对实验动物脑缺血再灌注损伤的影响。结果表明，ＴＰ对缺血再灌注损伤的海马组织中超氧化物歧化酶（ＳＯＤ）、谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）、Ｎａ＋－Ｋ＋ＡＴＰａｓｅ、Ｃａ２＋－ＡＴＰａｓｅ等酶的活性均有明显的保护作用，同时使丙二醛（ＭＤＡ）含量明显下降。结果提示ＴＰ具有较强的抗氧化作用，对脑缺血再灌注损伤有保护作用。
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| 关 键 词： | 茶多酚 脑缺血 再灌注损伤 抗氧化作用 |
The Protective Effects of Tea Polyphenols onCerebral Ischimia-reperfusion Injury in Rats |
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| Li lizhons,et al..The Protective Effects of Tea Polyphenols onCerebral Ischimia-reperfusion Injury in Rats[J].Pharmacology and Clinics of Chinese Materia Medica,1996,12(3):18-20. |
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| Authors: | Li lizhons |
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| Abstract: | n order to oberve the influence of Tea Polyphenols (TP) on cerebral ischemia-reperfusion injury in rats, theexperimental model was established by lisaturins both sides of common carotid artery for 30 minutes followed byreperfusing for 60 minutes in rats. The data showed that TP sisnificantly decreased level of MDA and had obviouslya protective effect on activity of Superoxide Dismutase, Glutathione PerokidaSe, Na -K ATPase and Ca -ATPasein the hippocamp of brain that underwent ischemia following reperfusion in rats. The results suggested that TP haveprotective effect on cerebral ischemia reperfusion injury and its mechanism misht be related to itS anti-oxidation. |
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| Keywords: | Tea Polyphenols (TP) cerebral ischcmia reperfusion ijury anti-oxidation action |
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