| 黄连解毒汤提取物对脑缺血小鼠学习记忆的促进作用 |
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| 引用本文： | 徐静华,李立志,等.黄连解毒汤提取物对脑缺血小鼠学习记忆的促进作用[J].中药药理与临床,1998,14(6):6-9. |
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| 作者姓名： | 徐静华 李立志 |
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| 作者单位： | 沈阳药科大学中药药理教研室，沈阳市铁西区中医院 |
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| 摘 要： | 采用避暗法和水迷宫法研究了黄连解毒汤提取物对实验性慢性脑缺血小鼠的作用。结果表明，黄连解毒汤提取物０５ｇ／ｋｇ、１０ｇ／ｋｇ能显著减少脑缺血小鼠避暗错误次数，并延长其钻洞潜伏期；提取物０５ｇ／ｋｇ、１０ｇ／ｋｇ和２０ｇ／ｋｇ均能显著增加脑缺血小鼠在水迷宫中的正确反应次数；且对脑缺血小鼠脑内丙二醛的生成有显著抑制作用。
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| 关 键 词： | 黄连解毒汤 脑缺血 学习记忆 丙二醛 |
The Improving Effect of Huanglian Jiedu Tang Extract on Learning and Memory in Cerebral Ischemia Mice |
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| Xu Jinghua,Yu Qinghai,Yang Xianwen,Shen Jia,Li Xia.The Improving Effect of Huanglian Jiedu Tang Extract on Learning and Memory in Cerebral Ischemia Mice[J].Pharmacology and Clinics of Chinese Materia Medica,1998,14(6):6-9. |
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| Authors: | Xu Jinghua Yu Qinghai Yang Xianwen Shen Jia Li Xia |
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| Abstract: | The improving effect of Huanglian Jiedu Tang extract (HJTE) on learning and memory in cerebral ischemia mice was studied by step through method and water maze method.The experimental results showed that whth HJTE ig in the dose of 0.5g/kg,1.0g/kgx,step through error numbers of cerebral ischemia mice were significantly reduced and step through latency was notably deferred,that in the dose of 0.5g/kg,1.0g/kg and 2.0g/kg,current response numbers of water maze test were markedly increased in cerebral ischemia mice and MDA content of brain was siginficantly inhibited. |
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| Keywords: | Huanglian Jiedu Tang(HJT) cerebral ischemia learning and memory MDA |
| 本文献已被 CNKI 维普 等数据库收录！ |
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