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"脾虚"大鼠胃壁细胞胃泌素受体变化及补中益气汤的作用
引用本文:许琦,王汝俊,陈芝喜,王建华,刘晓玲."脾虚"大鼠胃壁细胞胃泌素受体变化及补中益气汤的作用[J].中药药理与临床,2003,19(2):3-5.
作者姓名:许琦  王汝俊  陈芝喜  王建华  刘晓玲
作者单位:1. 广州中医药大学2000级博士生,,广州,510405
2. 广州中医药大学,核医学教研室,广州,510405
3. 广州中医药大学,脾胃研究所,广州,510405
4. 广州中医药大学2001级硕士研究生,广州,510405
基金项目:广东省自然科学基金资助资助编号 :No.980 640,国家自然科学基金项目资助 (NO .30 2 71 650 )
摘    要:目的:研究“脾虚”和经补中益气汤治疗后的大鼠胃壁细胞胃泌素受体的变化。方法:放射配基受体结合分析法。结果:虽然“脾虚”大鼠胃壁细胞胃泌素受体的结合位点数低于正常大鼠,但其亲和力高于正常大鼠。经补中益气汤治疗后对其具有复健作用。结论:胃泌素受体的结合位点数显减少,可能导致脾虚大鼠胃黏膜的防御性下降;而亲和力显增高可能是黏膜对攻击因子的敏感性增强的机制之一。补中益气汤通过调节胃泌素受体对脾虚具有复健作用。

关 键 词:脾虚  胃壁细胞  胃泌素受体  补中益气汤  中药

Effect of Buzhong Yiqi Tang (补中益气汤) on the gastrin receptors in the gastric parietal cells in rat with deficiency of the spleen
Xu Qi,Chen Zhixi,Wang Rujun Wang Jianhua,Liu Xiaoling.Effect of Buzhong Yiqi Tang (补中益气汤) on the gastrin receptors in the gastric parietal cells in rat with deficiency of the spleen[J].Pharmacology and Clinics of Chinese Materia Medica,2003,19(2):3-5.
Authors:Xu Qi  Chen Zhixi  Wang Rujun Wang Jianhua  Liu Xiaoling
Abstract:Objective: To study the effect of buzhong yiqi tang on the gastrin receptors in the gastric parietal cells in rat with deficiency of the spleen. Methods: Gastrin receptors were analyzed in gastric parietal cells preparations using I-labeled 15-Leu-gastrin-17 as label. Results: A significant decrease in the number of gastrin receptors (Bmax), while a significant increase in the gastrin receptor affinity in rats with deficiency of the spleen. After treated by buzhong yiqi tang the condition reversed. Conclusion: Buzhong yiqi tang can increase the number of gastrin receptors (Bmax), decrease the gastrin receptor affinity in rats with deficiency of the spleen.
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