| 人参皂苷M1月桂酸酯的合成与结构研究(英文) |
| |
| 引用本文： | 李文芳,李争宁,陈丽荣,弓晓杰.人参皂苷M1月桂酸酯的合成与结构研究(英文)[J].中国天然药物,2011(3):199-203. |
| |
| 作者姓名： | 李文芳 李争宁 陈丽荣 弓晓杰 |
| |
| 作者单位： | 大连大学环境与化学工程学院;大连大学医学院; |
| |
| 基金项目： | supported by the National Natural Science Foundation (Nos.30873155 and 30973625)~~ |
| |
| 摘 要： | 目的:研究人参皂苷M1酯化产物的结构。方法:用月桂酸、二亚胺与M1进行酯化反应,采用柱硅胶层析法分离纯化,利用IR,UPLC/QTOFMS和NMR(1D和2DNMR)等现代波谱技术手段鉴定了它们的结构。结果:分离得到了三种化合物,其中它们的结构分别为M1结构中葡萄糖单元3-OH,4-OH,6-OH位引入酯基。结论:在M1中葡萄糖单元上发生酰化反应,合成出三种新的M1衍生物。
|
| 关 键 词： | 人参皂苷代谢物M1 酯化产物 合成 NMR |
Synthesis and Structural Analysis of Mono-dodecanoic Acid Esters of Ginsenoside M1 |
| |
| LI Wen-Fang ,LI Zheng-Ning ,Chen Li-Rong ,GONG Xiao-Jie School of Chemical , Environmental Engineering,Dalian University,Dalian ,China,School of Medical.Synthesis and Structural Analysis of Mono-dodecanoic Acid Esters of Ginsenoside M1[J].Chinese JOurnal of Natural Medicines,2011(3):199-203. |
| |
| Authors: | LI Wen-Fang LI Zheng-Ning Chen Li-Rong GONG Xiao-Jie School of Chemical Environmental Engineering Dalian University Dalian China School of Medical |
| |
| Institution: | LI Wen-Fang 1,LI Zheng-Ning 1,Chen Li-Rong 1,GONG Xiao-Jie 21School of Chemical and Environmental Engineering,Dalian University,Dalian 116622,China,2School of Medical |
| |
| Abstract: | AIM:To study the structures of esterification products derived from ginsenoside M1 and dodecanoic acid.METHOD:The esterified compounds were prepared from the reaction of ginsenoside M1 dodecanoic acid and diimide,and pure prodcuts were obtained by Silica gel column chromatography.Their structures were characterized by IR,UPLC/Q TOF MS and NMR(1D and 2D NMR).RESULTS:Structures of three compounds were elucidated as the esetrified M1 acylated at 3-OH,4-OH,6-OH in the glucose moiety in M1,respectively.CONCLUSIO... |
| |
| Keywords: | Ginsenoside metabolite M1 Esterification products Synthesis NMR |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
