天然产物中的抗补体活性成分

补体系统的非正常激活会引发类风湿性关节炎、老年性痴呆、急性呼吸窘迫综合征以及系统性红斑狼疮等多种疾病。目前临床上尚无高效、低毒、专一的补体抑制剂。国内外已完成部分天然产物的筛选,发现自然界中广泛存在的某些多糖、黄酮、甾类和萜类化合物具有显著的抗补体活性。本文对天然产物类抗补体活性成分的研究方法、已发现活性化合物的化学结构以及体内外药理研究概况进行综述,并分析了天然产物类补体抑制剂的应用前景。

Anti-complementary Agents from Natural Products

Inappropriate activation of complement is involved in the pathogenesis of many auto-immune disorders, inflammatory diseases and inflammation responses seen in the conditions such as cardiopulmonary by-pass and bacterial infections. But there is still no desirable therapeutic compound available on the market for complement inhibition. Numerous naturally occurring agents have been shown to have anti-complementary effects, and they offer the prospect of inexpensive and non-toxic strategies for the therapeutic inhibition of complement. In the present paper, the natural anticomplementary ingredients are summarized and classified according to their chemical nature and complement inhibiting efficacy, especially the future application of them was highlighted. The approaches used to develop the natural occurring anticomplementary agents were also discussed in this report.