| 茴香醛、茴香脑以及肉桂醛对5-氟脲嘧啶体外透皮吸收的影响 |
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| 引用本文： | 沈琦,孙霞,邱明丰,贾伟,徐莲英.茴香醛、茴香脑以及肉桂醛对5-氟脲嘧啶体外透皮吸收的影响[J].中国天然药物,2005,3(2):101-105. |
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| 作者姓名： | 沈琦 孙霞 邱明丰 贾伟 徐莲英 |
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| 作者单位： | 1. 上海交通大学药学院,上海,200030
2. 上海中医药大学药学院,上海,201203 |
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| 摘 要： | 目的 :考察茴香醛、茴香脑以及肉桂醛对 5 -氟脲嘧啶体外透皮吸收的影响。方法 :采用扩散池技术 ,以裸鼠皮肤为实验材料 ,考察 5 -氟脲嘧啶的透皮吸收情况。结果 :以上三种挥发性成分 (2 % ,w/v)在联合使用 2 0 %乙醇或者30 %丙二醇时 ,都可以显著提高 5 -氟脲嘧啶的透皮吸收系数 (P <0.0 1)。结论 :茴香醛、茴香脑和肉桂醛联合使用乙醇或者丙二醇可以用于促进 5 -氟脲嘧啶的透皮吸收
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| 关 键 词： | 5-氟脲嘧啶 透皮吸收促进剂 茴香醛 茴香脑 肉桂醛 扩散池技术 裸鼠 透皮吸收 中药材 |
Effect of Anisaldehyde,Anethole and Cinnamaldehyde on the in vitro Percutaneous Absorption of 5-Fluorouracil |
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| SHEN Qi,SUN Xia,QIU Ming-Feng,JIA Wei,XU Lian-Ying.Effect of Anisaldehyde,Anethole and Cinnamaldehyde on the in vitro Percutaneous Absorption of 5-Fluorouracil[J].Chinese JOurnal of Natural Medicines,2005,3(2):101-105. |
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| Authors: | SHEN Qi SUN Xia QIU Ming-Feng JIA Wei XU Lian-Ying |
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| Abstract: | AIM:To investigate the effects of anisaldehyde,anethole and cinnamaldehyde on the in vitro percutaneous permeation of 5-fluorouracil (5-FU).METHOD:The percutaneous permeation of 5-FU was investigated in hairless mouse skin after application of cinnamaldehyde,anethole,or anisaldehyde with ethanol or propylene glycol (PG) using a diffusion cell technique.RESULT:The above volatile constituents (2%,w/v) in combination with 20% ethanol or 30% PG significantly increased the permeability coefficient of 5-FU (P<0.01) in comparison with the control.CONCLUSION:Anisaldehyde,anethole and cinnamaldehyde in combination with ethanol or propylene glycol can be used to enhance the percutaneous absorption of 5-FU. |
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| Keywords: | Fluorouracil Percutaneous penetration enhancer Anisaldehyde Anethole Cinnamaldehyde |
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