| 奇乳海参中两个具有抗真菌活性的三萜皂苷 |
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| 引用本文： | 袁卫华,易杨华,薛梅,张宏伟,喇明平.奇乳海参中两个具有抗真菌活性的三萜皂苷[J].中国天然药物,2008,6(2):105-108. |
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| 作者姓名： | 袁卫华 易杨华 薛梅 张宏伟 喇明平 |
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| 作者单位： | 第二军医大学药学院海洋药物研究中心,上海,200433 |
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| 基金项目： | 国家高技术研究发展计划(863计划) |
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| 摘 要： | 目的：研究奇乳海参体内的化学成分，寻找结构新颖具有抗真菌活性的三萜皂苷类成分。方法：应用多种色谱分离技术对奇乳海参体内的化学成分进行分离纯化，根据化合物的理化性质，波谱数据及化学方法鉴定其结构。结果：分离得到2个三萜皂苷化合物，分别为axilogoside A（1）和holothurin B（2），并对其抗真菌活性进行了研究（4≤MIC80≤16μg·mL^-1）。结论：化合物1为一新的三萜皂苷化舍物，化合物2为首次从奇乳海参中分离得到，它们均显示一定的抗真菌活性。
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| 关 键 词： | 奇乳海参 三萜皂苷 抗真菌活性 |
| 文章编号： | 1672-3651(2008)02-0105-04 |
| 修稿时间： | 2007年12月11 |
Two Antifungal Active Triterpene Glycosides from Sea Cucumber Holothuria (Microthele) axiloga |
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| YUAN Wei-Hua,YI Yang-Hua,XUE Mei,ZHANG Hong-Wei,LA Ming-Ping.Two Antifungal Active Triterpene Glycosides from Sea Cucumber Holothuria (Microthele) axiloga[J].Chinese JOurnal of Natural Medicines,2008,6(2):105-108. |
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| Authors: | YUAN Wei-Hua YI Yang-Hua XUE Mei ZHANG Hong-Wei LA Ming-Ping |
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| Institution: | (Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, Shanghai 200433, P. R. China Available online： 20 March 2008) |
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| Abstract: | AIM: To study the new antifungal active triterpene glycosides of sea cucumber Holothuria (Microthele) axiloga. METHODS: Triterpene glycosides from Holothuria (Microthele) axiloga were separated and purified by silica gel chromatography, reversed-phase silica gel chromatography and RP-HPLC. Their structures were elucidated on the basis of chemical evidence, spectral data and chemical reactions. RESULTS: Two triterpene glycosides were identified as axilogoside A (1) and holothurin B (2). CONCLUSION: Axilogoside A (1) is a new triterpene glycoside, and 2 Was isolated from Holothuria (Microthele) axiloga for the first time. They showed considerable antifungal activities (4≤MIC80≤16μg·mL-1). |
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| Keywords: | Holothuria axiloga Triterpene glycoside Antifungal activity |
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