长白瑞香的化学成分

目的：研究产自长白山地区的长白瑞香（Daphne koreana）的化学成分。方法：应用硅胶柱色谱,Sephadex LH-20和RP-18反相柱色谱的方法分离和纯化化合物,通过光谱方法及理化性质鉴定化合物结构。结果：从长白瑞香氯仿部位分离得到10个化合物,分别为：双白瑞香苷（1）,7-甲氧基-木犀草素-5-O-β-D-葡萄糖苷（2）,樱花苷（3）,芫花苷（4）,瑞香新素（5）,异瑞香新素（6）,5-去甲氧基瑞香新素（7）,紫丁香苷（8）,左旋松脂酚（9）,左旋松脂酚-4-O-β-D-葡萄糖苷（10）。结论：所有化合物均为首次从该植物中分得。

Chemical Constituents from Daphne koreana Nakai

AIM: To study the chemical constituents of the stems and barks of Daphne koreana from the hangbai Mountain in the North of China.METHODS: Compounds were separated by column chromatography with silica gel,Sephadex LH-20 and RP-18 silica gel.Their structures were elucidated on the basis of physiochemical and spectral analyses.RESULTS: Ten compounds were isolated from D.koreana and the structures were identified as daphnoretin-7-O-β-D-glucopyranoside (1), luteolin-7-methylether-5-O-β-D-glucopyranoside (2), sakuranin (3),yuankanin (4), daphneticin (5), isodaphneticin (6), 5'-demethoxydaphneticin (7), syringin (8), (-)-pinoresinol (9) and(-)-pinoresinol-4-O-β-D-glucopyranoside (10).CONCLUSION: Compounds 1～10 were isolated from this plant for the first time.KEY WORDS] Daphne koreana; Thymelaeaceae; Chemical constituentsCLC Number] R284.1Document code] A Aiticle ID] 1672-3651(2008)06-0411-04Foundation Item] This project was supported by the Science and Technology Commission Foundation of Shanghai (No.05DZ 19733)