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博落回中两个新苯并菲啶类异喹啉生物碱(英文)
引用本文:冯锋,叶冯芝,李彩莲,柳文媛,谢宁.博落回中两个新苯并菲啶类异喹啉生物碱(英文)[J].中国天然药物,2012(5):378-382.
作者姓名:冯锋  叶冯芝  李彩莲  柳文媛  谢宁
作者单位:[1]中国药科大学天然药物化学教研室,南京210009 [2]中国药科大学药物分析教研室,南京210009 [3]江西青峰药业有限公司,赣州341000
基金项目:中央高校基础研究项目(No.ZJ10015,JKP2011009)资助
摘    要:目的:对中药博落回的化学成分进行研究。方法:依次采用阳离子交换树脂、硅胶、Sephadex LH-20 柱色谱法和重结晶等分离技术, 对博落回的生物碱进行分离。并运用多种光谱技术对所得生物碱的结构进行鉴定。结果:从博落回中分离并鉴定了 6 个苯并菲啶类异喹啉生物碱:6α-iso-butanonyldihydrosanguinarine (1), 6α-iso-butanonyldihydrochelerythrine (2), 6-丙酮基二氢血根碱(6-acetonyldihydrosanguinarine, 3), 6-丙酮基二氢白屈菜红碱(6-acetonyl-dihydrochelerythrine, 4), 二氢血根碱(dihydrosanguinarine, 5)、二氢白屈菜红碱(dihydrochelerythrine, 6)。结论:苯并菲啶类异喹啉生物碱是中药博落回的典型化学成分。化合物 1 和 2 为新化合物。

关 键 词:博落回  苯并菲啶异喹啉生物碱  6α-iso-butanonyldihydrosanguinnarine  6α-iso-butanonyldihydrochelerythrine

Two new benzo phenanthridine isoquinoline alkaloids from Macleaya cordata
FENG Feng,YE Feng-Zhi,LI Cai-Lian,LIU Wen-Yuan.,XIE Ning.Two new benzo phenanthridine isoquinoline alkaloids from Macleaya cordata[J].Chinese JOurnal of Natural Medicines,2012(5):378-382.
Authors:FENG Feng  YE Feng-Zhi  LI Cai-Lian  LIU Wen-Yuan  XIE Ning
Institution:1Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China; 2Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, China; 3Jiangxi Qingfeng Pharmaceutical Co., Ltd., Ganzhou 341000, China
Abstract:AIM: To study the chemical constituents of Macleaya cordata (Willd.) R. Br. METHODS: Crude alkaloids were isolated and purified from the fruits with column chromatography of cation exchange, silica gel ad Sephadex LH-20 followed by re- crystallization. The structure elucidation was carried out by extensive spectroscopic methods. RESULTS: Two new benzophe- nanthridine isoquinoline alkaloids, 6a-iso-butanonyldihydrosanguinarine (1) and 6a-iso-butanonyldihydrochelerythrine (2), along with other four known alkaloid compounds, 6-acetonyldihydrosanguinarine (3), 6-acetonyldihydrochelerythrine (4), dihydrosanguinarine (5) and dihydrochelerythrine (6) have been isolated from fruits of M. cordata collected in Anhui Province of China. CONCLUSION: Benzophenanthridine isoquinoline alkaloids are featured in M. cordata. Compounds I and 2 are new ones.
Keywords:Macleaya cordata  Benzophenanthridine alkaloids  6a-Iso-butanonyldihydrosanguinnarine  6a-lso-butanonyldihy-drochelerythrine
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