白木香中的黄酮类成分(英文)

目的:研究白木香茎木的化学成分。方法:运用硅胶、凝胶柱色谱和高效液相色谱等方法进行化合物的分离纯化。通过理化鉴别和波谱解析进行结构鉴定。结果:分离鉴定了12个黄酮类化合物,分别为白木香苷A1(1),lethediosideA(2),7,4′-二甲氧基洋芹素-5-O-木糖葡萄糖苷(3),lethedosideA(4),7-羟基-4′-甲氧基-5-O-葡萄糖黄酮苷(5),7,3′-二甲氧基-4′-羟基-5-O-葡萄糖黄酮苷(6),7,4′-二甲氧基-5-O-葡萄糖黄酮苷(7),洋芹素-7,4′-二甲醚(8),木犀草素-7,3′,4′-三甲醚(9),羟基芫花素(10),金合欢素(11),芒柄花素(12)。结论:化合物1为新黄酮苷,化合物2,4-7为首次从该属植物中分离得到。分离得到的5-O-黄酮苷化合物1-7具有抑制LPS诱导巨噬细胞生成NO活性。

Flavanoids from the stems of Aquilaria sinensis

AIM： To study the chemical constituents from the stems of Aquilaria sinensis （Lour.） Gilg. METHODS： Chromatographic separations of silica gel, Sephadex LH-20 and prep-HPLC were used. All the structures were elucidated on the basis of chemical and spectroscopic analysis. RESULTS： Twelve flavonoids were isolated and their structures were identified as aquilarinoside AI （1）, lethedioside A （2）, 7, 4＇-dimethylapigenin-5-O-xylosylglucoside （3）, lethedoside A （4）, 7-hydroxyl-4＇-methyl-5-O- glucoside- flavonoid （5）, 7, 3＇-dimethyl-4＇-hydroxyl-5-O-glucosideflavonoide （6）, 7, 4＇-dimethyl-5-O-glucosideflavonoide （7）, 5-hydroxyl-7, 4＇-dimethoxyflavone （8）, luteolin-7, 3＇, 4＇-trimethyl （9）, hydroxylgenkwanin （10）, 5, 7-dihydroxyl-4＇-methoxyflavone （11）, and formononetin （12）. CONCLUSION： Compound 1 is a new flavone glycoside, and compounds 2, 4-7 were isolated from genus Aquilaria sinensis for the first time. 5-O-glycosylflavones 1-7 showed inhibitory activity for nitric oxide （NO） production by activated RAW 264.7 ceils.