毛叶香茶菜中的二萜化合物

目的：对河南产毛叶香茶菜化学成分进行研究。方法：运用各种色谱技术和波谱分析对其化学成分进行分离鉴定。结果：分离鉴定了20个二萜化合物。结论：化合物1—3为三个新的对映-贝壳杉烷二萜类化合物，结构分别为7β，15β，16β—三羟基—6β，17β—二乙酰氧基—7α，20-环氧—对映—贝壳衫烷(1)、16（S)—6β，11α，17β—三羟基-6，20-环氧—1α，7β—内酯—6，7—断裂—对映—贝壳杉-15酮(2)和6α，11α—二海基—1α—乙酰氧基—7，20内酯—6，7—断裂—对映—贝壳杉—16—烯—15—酮(3)，依次命名为毛叶香茶菜丙素、丁素和戊素；化合物4和5为—对新化合物，其结构为3α，15α，1β6，17β，18β—五羟基。对映—松香—7(8)—烯的丙酮化物，其丙酮化缩合部分互为对映体，分别命名为毛叶香茶菜庚素(4)和辛素(5)。

Diterpenoids from Isodon japonicus

AIM:To study the chemical constituents of Isodon japonicus. METHOD: We isolated and elucidated the chemical constituents using chromatographic techniques and spectral analysis. RESULT and CONCLUSION:Twenty diterpenoids including three new ent-kauranoids (1-3) and a pair of epimers of new ent-abietanoid (4 and 5) were isolated and identified. These five new diterpenoids are 7β, 15β, 16β-trihydroxy-6β, 17-diacetoxy-7α, 20-epoxy-ent-kaurane (1) ,16(S)-6β,11α, 17-trihydroxy-6,20-epoxy- 1α, 7-olide-6,7-seco-ent-kaur-15-one (2), 11α-dihydroxy-1α-acetoxy-7,20-olide-6,7-seco-ent-kaur-16-en-15-one (3) , 15(S)-3α, 17, 18-trihydroxy-ent-abieta-7(8)-en-15,16-acetonide (4), 15(R)-3α,17,18-trihydroxy-ent-abieta- 7(8)-en-15,16-acetonide (5), and named maoyecrystals C-E, G and H, respectively. The13C NMR data of lasiokaurin (13) is reported in this paper for the first time.