| 地不容块茎中的生物碱 |
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| 引用本文： | 金慧子,王红兵,王玉波,林丽萍,丁健,秦国伟.地不容块茎中的生物碱[J].中国天然药物,2007,5(2):112-114. |
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| 作者姓名： | 金慧子 王红兵 王玉波 林丽萍 丁健 秦国伟 |
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| 作者单位： | 中国科学院上海生命科学院上海药物研究所,上海,201203 |
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| 摘 要： | 目的:研究地不容Stephania epigaea Lo中具有细胞毒活性的化学成分。方法:利用反复硅胶色谱柱进行分离纯化,通过理化性质和光谱数据分析鉴定化合物结构。结果:分离得到6个生物碱,分别鉴定为千金藤素( )-cepharan-thine(1),轮环藤宁cycleanine(2),(-)-norcycleanine(3),isochondodendrine(4),delavaine(5)和runanine(6)。结论:生物碱3～6为首次从该植物中分得,1～4体外有肿瘤细胞毒活性。
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| 关 键 词： | 地不容 生物碱 肿瘤细胞毒活性 |
| 文章编号： | 1672-3651（2007）02-0112-03 |
| 修稿时间： | 2006-08-09 |
Alkaloids from Stephania epigaea |
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| JIN Hui-Zi,WANG Hong-Bing,WANG Yu-Bo,LIN Li-Ping,DING Jian,QIN Guo-Wei.Alkaloids from Stephania epigaea[J].Chinese JOurnal of Natural Medicines,2007,5(2):112-114. |
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| Authors: | JIN Hui-Zi WANG Hong-Bing WANG Yu-Bo LIN Li-Ping DING Jian QIN Guo-Wei |
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| Institution: | Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China |
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| Abstract: | AIM: To study the alkaloids of Stephania epigaea Lo and their cytotoxicities against several cancer cell lines. METHODS: Alkaloids were isolated by column chromatography and their structures were elucidated by spectroscopic analysis. RESULTS: Six known alkaloids including (+)-cepharanthine (1), cycleanine (2),(-)-norcycleanine (3), isochondodendrine (4), delavaine (5) and runanine (6) were isolated from the plant. CONCLUSION: Alkaloids 3～6 were first isolated from the plant. Alkaloid 1 exhibited potent cytotoxicities against Ramos, A549, and P388 cell lines. Alkaloids 2～4 showed potent cytotoxicities against Ramos cells. |
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| Keywords: | Stephania epigaea Alkaloids Cytotoxicity |
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