| 黄芪总黄酮对缺血再灌注损伤模型中一氧化氮的作用及其 … |
| |
| 引用本文： | 汪德清,王成彬.黄芪总黄酮对缺血再灌注损伤模型中一氧化氮的作用及其 …[J].中国中西医结合杂志,1999,19(4):221-223. |
| |
| 作者姓名： | 汪德清 王成彬 |
| |
| 作者单位： | 北京解放军总医院 |
| |
| 摘 要： | 目的：研究黄芪总黄酮（ｔｏｔａｌｆｌａｖｏｎｏｉｄｓｏｆａｓｔｒａｇａｌｕｓ，ＴＦＡ）对缺血再灌注损伤的防护作用。方法：应用家兔失血性休克／再灌注模型（ｓｈｏｃｋ／ｒｅｐｅｒｃｕｓｓｉｏｎ，Ｓ／Ｒ）观察损伤后血浆中一氧化化氮（ｎｉｔｒｉｃｏｘｉｄｅ，ＮＯ）代谢终产物亚硝酸盐（ＮＯ＾－２）的变化及ＴＦＡ和磷脂酶Ａ２阻断剂氯喹（Ｃｈｌｑ）治疗对其的影响。结果：数据表明Ｓ／Ｒ后２４ｈ内血浆中ＮＯ＾－２含
|
| 关 键 词： | 黄芪总黄酮 休克 缺血 一氧化氮 再灌注损伤 |
Effect of Total Flavonoids of Astragalus on Nitroxide in Ischemia Reperfusion Injury |
| |
| Authors: | D Wang C Wang Y Tian |
| |
| Institution: | General Hospital of PLA, Beijing, China. |
| |
| Abstract: | OBJECTIVE: To study the protective effect of total flavonoids of Astragalus (TFA) on ischemia/reperfusion injury. METHODS: Change of nitrite (NO2-), the terminal product of nitric oxide (NO) metabolism, and the effect of TFA and chloroquine (a phospholipase A2 inhibitor) on it were observed with hemorrhagic shock/reperfusion injury (S/R) rabbit model. RESULTS: Plasma NO2- content was positively correlated with blood pH and total carbon dioxide content lowering. TFA and chloroquine could block the decrease of NO in certain degree and might have some effect on maintaining acid-base balance of body. CONCLUSION: TFA has protective effect on ischemia/reperfusion injury. |
| |
| Keywords: | total flavonoids of Astragalus shock ischemia/reperfusion nitric oxide |
| 本文献已被 维普 等数据库收录！ |
