黄芪注射液配合化疗对晚期非小细胞肺癌患者生存质量的影响 |
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引用本文: | 邹雨荷,刘雪梅.黄芪注射液配合化疗对晚期非小细胞肺癌患者生存质量的影响[J].中国中西医结合杂志,2003,23(10):733-735. |
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作者姓名: | 邹雨荷 刘雪梅 |
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作者单位: | 广东省江门市中心医院,广东,529071 |
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摘 要: | 目的:观察黄芪注射液配合化疗对晚期非小细胞肺癌(non-small cell lung cancei,NSCLC)患者生存质量的影响。方法:60例晚期NSCLC患者随机分为黄芪注射液加化疗组(治疗组)30例和单纯化疗组(对照组)30例,两组化疗均采用MVP方案,治疗组同时辅以黄芪注射液60ml/天静脉滴注,21~28天为1个周期,治疗2~3个周期。结果:治疗组有效率为40.0%,对照组为36.7%;治疗、对照组平均缓解期、中位生存期及1年生存率分别为5.4个月和3.3个月,11个月和7个月,46.7%和30.0%,差异均有显著性(P<0.05);患者的临床症状总改善率,生存质量提高阳性率,治疗组为80.4%,43.3%,与对照组(50.0%,23.3%)比较,差异有显著性(P<0.01)。结论:黄芪注射液配合化疗可显著改善晚期NSCLC患者的生存质量。
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关 键 词: | 黄芪注射液 化疗 晚期 非小细胞肺癌 生存质量 影响 |
修稿时间: | 2003年5月23日 |
Effect of Astragalus Injection Combined with Chemotherapy on Quality of Life in Patients with Advanced Non-small Cell Lung Cancer |
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Authors: | ZOU Yu-he and LIU Xue-mei |
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Abstract: | Objective: To observe the effect of Astragalus injection (AI) combined with chemotherapy on quality of life (QOF) in patients with advanced non-small cell lung caner (NSCLC). Methods: Sixty NSCLC patients were randomly divided into the treated group (n=30,treated with AI combined with chemotherapy) and the control group (n=30, treated with chemotherapy alone). Chemotherapy of MVP protocol was applied to both groups. AI was supplemented to the treated group by intravenous dripping 60 ml per day. Treatment of 21-28 days as one treatment cycle, and 2-3 treatment cycles were applied. Results: The effective rate in the treated group was 40.0% and in the control group was 36.7%, the mean remission rate in the treated and control group was 5.4 months and 3.3 months, the median survival period 11 months and 7 months, and the 1-year survival rate 46.75% and 30.0%, respectively, the differences of these indexes between the two groups were all significant (P<0.05). Moreover, the clinical improving rate and QOF elevation rate in the treated group was 80.4% and 43.3%, as compared with those in the control group (50.0% and 23.3% respectively), the difference was also significant (P<0.01). Conclusion: AI combined with chemotherapy can significantly improve the QOF in NSCLC patients of advanced stage. |
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Keywords: | Astragalus injection chemotherapy non-small cell lung cancer quality of life |
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