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何首乌脑保护作用机理研究的进展
引用本文:王巍,王丹巧.何首乌脑保护作用机理研究的进展[J].中国中西医结合杂志,2005,25(10):955-959.
作者姓名:王巍  王丹巧
作者单位:中国中医研究院西苑医院老年医学研究所,北京,100091
摘    要:本文就近10年何首乌及其提取物有效成分二苯乙烯苷(2,3,5,4’-四羟基二苯乙烯-β-D-葡萄糖苷)对脑保护作用的机理研究进行了综述。它们的主要作用如下:(1)钙通道拮抗剂的作用;(2)抗氧化剂的作用;(3)拟胆碱药和胆碱脂酶抑制剂的作用;(4)调节细胞凋亡;(5)延缓衰老。何首乌的脑保护作用机理是多靶点、多环节、多途径的。因此,何首乌在老年痴呆、帕金森氏病、血管性痴呆等老年神经系统疾病的防治中具有很高的应用价值。

关 键 词:学习记忆功能  脑保护作用  何首乌  二苯乙烯苷  机理研究  胆碱脂酶抑制剂  钙通道拮抗剂  神经系统疾病  老年痴呆  帕金森氏病
收稿时间:2005-02-25
修稿时间:2005-07-05

Progress of Study on Brain Protective Effect and Mechanism of Polygonum multiflorum
Authors:WANG Wei and WANG Dan-qiao
Institution:Institute of Geriatrics, Xiyuan Hospital, China Academy of Traditional Chinese Medicine, Beijing 100091
Abstract:This paper reviews the brain protective effect and mechanism of Polygonum multiflorum (PM), its extracts and active component, tetrahydroxystilbene-glucoside (2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucoside) published in recent decade. They have major effects as calcium channel antagonists, antioxidant, cholinomimetic drugs and cholinesterase inhibitors, as well as actions in regulating cell apoptosis and prolonging the ageing. The brain protective mechanism of PM is multi-target, multi-link and multi-way. Therefore, PM has great applicative value in prevention and treatment of senile neuropathies, such as Alzheimer's disease, Parkinson's disease and vascular dementia, etc.
Keywords:learning and memory ability  brain protective effects  Polygonum multiflorum  tetrahydroxystilbene-glucoside
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