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自拟行肠汤干预慢传输型便秘的结肠动力学研究及疗效分析
引用本文:张玲玲,张君,王玉中,王丹霞.自拟行肠汤干预慢传输型便秘的结肠动力学研究及疗效分析[J].中国中西医结合杂志,2009,29(5):403-406.
作者姓名:张玲玲  张君  王玉中  王丹霞
作者单位:漯河医学高等专科学校第三附属医院,河南漯河,462002
摘    要:目的 研究行肠汤加减干预对慢传输型便秘的结肠动力学的影响,观察其治疗慢传输型便秘的临床疗效。

关 键 词:慢传输型便秘  自拟行肠汤  结肠动力

Study on Colonic Motility and Efficacy Analysis in Patients with Slow-Transit Constipation Treated with Self-formulated Xingchang Decoction
Authors:ZHANG Ling-ling  ZHANG Jun  WANG Yu-zhong
Institution:ZHANG Ling-ling, ZHANG Jun, WANG Yu-zhong, et al (The Third Affiliated Hospital of Luohe Medical College, Henan (462002))
Abstract:Objective To observe the clinical efficacy of self-formulated Xingchang Decoction (XCD) in treating slow-transit constipation (S-I-C) and the dynamical parameters of colonic motility during XCD treatment. Methods One hundred and eighteen patients with STC were randomly assigned to the treatment group and the control group, 59 in each group. The treatment group was treated with XCD, and the control group was treated with mosapride, an intestinal energetic agent. The therapeutic course for both groups was 30 days. The 72-h colonic transition test was conducted and the symptom scores were observed before and after treatment; the adverse reaction rate and clinical efficacy were calculated after treatment; and the recurrence rate in one year was followed-up. Results Symptom scores were significantly improved in the treatment group after treatment, with the improvement significantly superior to that in the control group ( P 〈0.01 ). The cure rate and the total effective rate were 76.27% and 93.22% in the treatment group respectively, while they were 47.45% and 72.87% in the control group, showing significant difference between the two groups ( P 〈0. 01 ). Besides, the 1-year recurrence rate was significantly lower (χ2 = 10.40, P =0. 001 ) and the improvement of colonic motor function was more in the treatment group than those in the control group (P〈0.01 ). Only low incidence (5.08% in the treatment group and 8.47% in the control group) of mild gastrointestinal reactions was shown, which caused no influence on the treatment. Conclusion XCD could effectively improve the motility of the digestive tract, and it is effective and safe for the treatment of STC.
Keywords:slow-transit constipation  self-formulated Xingchang Decoction  colonic motility
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