中药狼疮定对系统性红斑狼疮患者血清可溶性白细胞介素-2受体和新喋呤水平的影响

目的：观察中药狼疮定对系统性红斑狼疮（ＳＬＥ）患者血清可溶性白细胞介素－２受体（sIL-2R）和新喋呤（neopterin）水平的影响，探讨其治疗ＳＬＥ可能的作用机理。方法：筛选４５例ＳＬＥ患者，随机分成两组，激素并用狼疮定组２５例，单用激素组２０例，运用ＥＬＩＳＡ双抗夹心法等检测用药前后sIL-2R、neopterin水平。结果：ＳＬＥ患者sIL-2R、neopterin水平明显高于健康人，活动期高于缓解期，且neopterin水平与血沉水平呈正相关性（r＝０.８６，Ｐ＜０.０１）；治疗后激素并用狼疮定组sIL-2R、neopterin水平，利于调节细胞免疫功能，使紊乱的免疫内环境趋于平衡。

Effect of Langchuangding on Serum Soluble Interleukin-2 Receptor and Neopterin Level in Patients of Systemic Lupus Erythematosus

Objective: In order to explore the therapeutic mechanism of Langchuangding (LCD) in treating systemic lupus erythematosus (SLE) by observation of its effect on serum soluble interleukin 2 receptor (sIL 2R) and neopterin level in SLE patients. Methods: Forty five patients of SLE were randomly divided into two groups, the 25 cases in the treated group were treated with LCD plus glucocorticoid (GCC) and the 20 cases in the control group were treated with GCC alone. The levels of sIL 2R and neopterin were observed before and after treatment by double antibody sandwich ELISA. Results: SLE patient showed higher levels of sIL 2R and neopterin than normal, and being higher in active stage than in remission stage. The level of neopterin was positively correlated with erythrocyte sedimentation rate (ESR) (r=0.86, P<0 01). After treatment, the levels of sIL 2R and neopterin were lowered significantly in the treated group than those in the control group (P<0 05). Conclusion: LCD could effectively reduce the serum levels of sIL 2R and neopterin in SLE patients, which would be beneficial to cellular immune functional regulation and induce the disturbed internal environment of immunity to homeostasis.